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197. Stahl SM, Fava M, Trivedi MH, Caputo A, Shah A, Post A. Agomelatine in the treatment<br />

of major depressive disorder: an 8-week, multicenter, randomized, placebo-controlled trial. J<br />

Clin Psychiatry. 2010;71(5):616-26.<br />

198. Zajecka J, Schatzberg A, Stahl S, Shah A, Caputo A, Post A. Efficacy and safety of agomelatine<br />

in the treatment of major depressive disorder: a multicenter, randomized, double-blind,<br />

placebo-controlled trial. J Clin Psychopharmacol. 2010;30(2):135-44.<br />

199. Singh SP, Singh V, Kar N. Efficacy of agomelatine in major depressive disorder: metaanalysis<br />

and appraisal. Int J Neuropsychopharmacol. 2012;25(3):417-28.<br />

200. Koesters M, Guaiana G, Cipriani A, Becker T, Barbui C. Agomelatine efficacy and acceptability<br />

revisited: systematic review and meta-analysis of published and unpublished randomised<br />

trials. Br J Psychiatry. 2013;203:179-87.<br />

201. European Agency for the Evaluation of Medicinal Products. CL3-021. Unpublished study,<br />

data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency<br />

for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http://<br />

www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/<br />

human/000915/WC500046226.pdf<br />

202. European Agency for the Evaluation of Medicinal Products. CL3-022. Unpublished study,<br />

data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency<br />

for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http://<br />

www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/<br />

human/000915/WC500046226.pdf<br />

203. European Agency for the Evaluation of Medicinal Products. CL3-024. Unpublished study,<br />

data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency<br />

for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http://<br />

www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/<br />

human/000915/WC500046226.pdf<br />

204. European Agency for the Evaluation of Medicinal Products. CL3-026. Unpublished study,<br />

data from EMA reports. En: CHMP Assessment Report for Valdoxan. European Agency<br />

for the Evaluation of Medicinal Products 2008 [citado 10 dic 2013]. Disponible en: http://<br />

www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/<br />

human/000915/WC500046226.pdf<br />

205. European Agency for the Evaluation of Medicinal Products. CL3-023. Unpublished study,<br />

data from EMA reports. En: CHMP Assessment Report for Valdoxan: European Agency<br />

for the Evaluation of Medicinal Products; 2008 [citado 10 dic 2013]. Disponible en: http://<br />

www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/<br />

human/000915/WC500046226.pdf<br />

206. Novartis. CAGO178A2303. Unpublished Study: Novartis; 2011 [citado 10 dic 2013].<br />

Disponible en: http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.<br />

do?trialResult=2659<br />

207. Novartis. CAGO178A2304. Unpublished Study: Novartis; 2011 [citado 10 dic 2013].<br />

Disponible en: http://www.novctrd.com/ctrdWebApp/clinicaltrialrepository/displayFile.<br />

do?trialResult=3420<br />

208. Goodwin GM, Emsley R, Rembry S, Rouillon F. Agomelatine prevents relapse in patients<br />

with major depressive disorder without evidence of a discontinuation syndrome: a 24-week<br />

randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2009;70(8):1128-37.<br />

209. Goodwin GM, Boyer P, msley R RF, de Bodinat C. Is it time to shift to better characterization<br />

of patients in trials assessing novel antidepressants? An example of two relapse prevention<br />

studies with agomelatine. Int Clin Psychopharmacol. 2013;28(1):20-8.<br />

Guía de Práctica Clínica sobre el manejo de la depresión en el adulto 249

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