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Abstracts (PDF file, 1.8MB) - Society for Risk Analysis

Abstracts (PDF file, 1.8MB) - Society for Risk Analysis

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SRA 2013 Annual Meeting <strong>Abstracts</strong><br />

M4-E.1 Zaleski, RT*; Qian, H; Money, CM; Rohde, A;<br />

ExxonMobil Biomedical Sciences Inc., CONCAWE;<br />

rosemary.t.zaleski@exxonmobil.com<br />

Specific Consumer Exposure Determinants (SCEDs) <strong>for</strong><br />

fuel and lubricant scenarios<br />

Under REACH, classified substances produced in more than 10<br />

tons per year require the development of exposure scenarios to<br />

ensure the safe use conditions of the substance and, further,<br />

communicate these conditions in the supply chain. The<br />

European Centre <strong>for</strong> Ecotoxicology and Toxicology of Chemicals<br />

Targeted <strong>Risk</strong> Assessment tool (ECETOC TRA) is a preferred<br />

screening tier exposure model <strong>for</strong> REACH, to assist in<br />

identifying safe use conditions. Consistent with REACH, the<br />

TRA is intentionally parameterized with conservative defaults<br />

<strong>for</strong> a broad range of consumer product uses. Because of the<br />

inherent conservatism of REACH process, much industry ef<strong>for</strong>t<br />

has been dedicated to better understanding consumer exposure<br />

determinants and strengthening the documentation and public<br />

availability of in<strong>for</strong>mation supporting their basis. As part of the<br />

revised TRAv3 (released in 2012), ECETOC developed the<br />

concept of Specific Consumer Exposure Determinants (SCEDs)<br />

to facilitate the delivery of more realistic estimates of consumer<br />

exposure. The SCED enables industrial sector groups and trade<br />

associations to use available in<strong>for</strong>mation on consumer use<br />

habits and practices to further refine the consumer exposure<br />

estimate <strong>for</strong> the product/substance. Based on recent public<br />

data, we have developed 9 SCEDs to cover a range of consumer<br />

fuel use scenarios and 4 SCEDs to better describe consumer<br />

lubricant use scenarios. The changes to the TRA defaults in<br />

these SCEDs help to more accurately describe current<br />

consumer uses in practice while retaining a conservative<br />

approach to the assessment of risk presented by each scenario.<br />

The Downstream Users of Chemical Coordination group<br />

(DUCC) is extending this concept to compile a library of SCEDs<br />

covering a range of consumer product sectors. The intent are<br />

that these materials, which will be public, can better describe<br />

the nature of current consumer exposures through various tools<br />

such as the TRA and the European Chemical Agency’s Chemical<br />

Safety Assessment and Reporting tool (CHESAR).<br />

M2-E.3 Zang, Y*; Carrington , CD; US FDA-CFSAN;<br />

Janet.Zang@fda.hhs.gov<br />

Cadmium: Parameters <strong>for</strong> the Estimation of Global<br />

Burden of Disease<br />

Cadmium is a toxic element widely distributed in foods. World<br />

Health Organization (WHO)’s Foodborne Disease Epidemiology<br />

Reference Group (FERG) has listed cadmium as one of the<br />

priority chemical hazards. To calculate cadmium-attributable<br />

disability-adjusted life year (DALY), it is essential to estimate<br />

the incidence of cadmium-related diseases around the world.<br />

Based on a thorough weight of evidence analysis and the<br />

disability weight in<strong>for</strong>mation from the WHO Global Burden of<br />

Disease report (GBD 2010), two cadmium-associated disease<br />

endpoints were selected: 1) stage 4-5 chronic renal disease<br />

(CKD), caused by the reduction of glomerular filtration rate<br />

(GFR); and 2) fracture, caused by the reduction of bone-mass<br />

density (BMD). Since cadmium-attributable disease rates are<br />

not available, an exposure-based method was used to indirectly<br />

estimate the incidence rates. First, cadmium exposures in<br />

different global regions were collected from the published<br />

urinary cadmium (U-Cd) levels as well as from the WHO<br />

GEMS/Food database. Based on the dose-response relationships<br />

between cadmium exposure and GFR or BMD, the magnitude of<br />

reduction in GFR or BMD were calculated <strong>for</strong> different global<br />

regions based on their exposure data. Next, the incidence rate<br />

of cadmium-attributable CKD stage 4-5 can be derived by<br />

calculating the distributional shift of GFR into

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