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Abstracts (PDF file, 1.8MB) - Society for Risk Analysis

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SRA 2013 Annual Meeting <strong>Abstracts</strong><br />

M4-E.2 Boelter, FW*; Xia, Y; Persky, JD; ENVIRON<br />

International; fboelter@environcorp.com<br />

Cumulative Exposures to Asbestos Fibers from Dropped<br />

Ceiling Installation and Maintenance<br />

Dropped ceilings began around 1940s to be used in commercial<br />

and to a lesser degree residential construction <strong>for</strong> better<br />

acoustics, modern appearance, reduction of heating and<br />

lighting costs, and compatibility with then-new suspended<br />

fluorescent lighting. Several fatal fires including the 1958 Our<br />

Lady of the Angels fire in Chicago in which combustible<br />

building materials including acoustic tiles were accused of<br />

costing loss of life, hastened the inclusion of fireproof asbestos<br />

in interior building materials until the mid to late 1970's. We<br />

developed an algorithm <strong>for</strong> the reconstruction of exposures to<br />

airborne asbestos fibers resulting from ceiling tile activities and<br />

implemented the algorithm using hypothetical work histories<br />

<strong>for</strong> five categories of people – specialty construction<br />

contractors, general building contractors, Do-It-Yourself<br />

nonprofessionals (DIYer), maintenance trades, and bystanders.<br />

We present new exposure data obtained through two field<br />

studies on asbestos-containing ceiling tiles removal and<br />

replacement and one chamber study involving cutting and<br />

installing such tiles. These data, coupled with professional<br />

judgment and mathematical modeling (Bayesian decision<br />

analysis and stochastic simulation), lead to the estimations of 8<br />

h time-weighted average (TWA) as well as 1-year and 10-year<br />

cumulative exposures to asbestos fibers from working with<br />

asbestos-containing ceiling tiles. Our results estimate mean<br />

1-year cumulative exposure expressed as f/cc-years to be 0.007<br />

<strong>for</strong> specialty construction contractors, 0.0004 <strong>for</strong> general<br />

building contractors, 0.00008 <strong>for</strong> Do-It-Yourself<br />

nonprofessionals, 0.004 <strong>for</strong> maintenance trades, and 0.0004 <strong>for</strong><br />

bystanders. The distributions of 8 h TWA dust and asbestos<br />

fiber exposures estimated <strong>for</strong> the five worker categories are<br />

compared to historical exposure data, while the cumulative<br />

exposure estimates are used to evaluate health risks. None of<br />

the five categories of workers receive a cumulative exposure<br />

(dose) that would significantly increase their risk <strong>for</strong> disease<br />

development.<br />

T2-H.1 Boerman, D*; Gallagher, M; Headquarters, U.S. Air<br />

Force; douglas.boerman@pentagon.af.mil<br />

U.S. Air Force <strong>Risk</strong> Assessment Framework<br />

The Headquarters of the United States Air Force has adopted<br />

major components of the Chairman of the Joint Chiefs of Staff's<br />

<strong>Risk</strong> Assessment System to develop a risk-based decision<br />

support approach to in<strong>for</strong>m major decisions, especially with<br />

regard to logistics. The major advantages of using the<br />

Chairman's system are improved clarity in internal Air Force<br />

decisions and improved risk communication between the Air<br />

Force and the Joint Staff. Use of a mature, rigorous process<br />

improves both identification of risk origin and credibility in<br />

communicating risk in<strong>for</strong>mation. This transition to a <strong>Risk</strong><br />

Assessment Framework is still underway and lessons learned in<br />

implementing a new risk approach within a complex<br />

government organization will benefit risk practioners in and out<br />

of government<br />

W4-B.3 Boffetta, P*; Mundt, KA; Mundt, DJ; Checkoway, H;<br />

Swenberg, J; Adami, H-O; Icahn School of Medicine at Mount<br />

Sinai, ENVIRON International Corporation University of<br />

washington, Seattle, University of North Carolina at Chapel<br />

Hill, Harvard University School of Public Health;<br />

paolo.boffetta@i-pri.org<br />

Integrating toxicological & epidemiological evidence of<br />

carcinogenicity: Application of Epid-Tox framework <strong>for</strong><br />

evaluating relationships between <strong>for</strong>maldehyde &<br />

nasopharyngeal cancer & myeloid leukemia<br />

Substantial scientific evidence is available to evaluate the<br />

carcinogenicity of <strong>for</strong>maldehyde. Although several evaluations<br />

have been conducted, none has <strong>for</strong>mally integrated<br />

toxicological and epidemiological evidence. Applying the<br />

Epid-Tox Framework <strong>for</strong> systematically combining toxicological<br />

and epidemiological evidence, as described by Adami et al.<br />

(2011), we present causal inference grids <strong>for</strong> the association<br />

between <strong>for</strong>maldehyde exposure and risks <strong>for</strong> nasopharyngeal<br />

cancer (NPC) and myeloid leukemia (ML). Separate grids are<br />

necessary because of the likely different modes of action, as<br />

well as the different epidemiological evidence <strong>for</strong> these two<br />

malignancies. For each grid, we applied the following steps<br />

separately <strong>for</strong> the toxicological and epidemiological evidence:<br />

1) we assessed the quality of primary research studies and<br />

categorize them as “acceptable”, “supplementary” or<br />

“unacceptable”; 2) we per<strong>for</strong>med a weight of evidence<br />

evaluation; and 3) we assigned a scalable conclusion regarding<br />

the strength or plausibility of the evidence, stated in terms of<br />

“evidence of effect” or “evidence of an absence of effect”. The<br />

scalable conclusions are simultaneously placed on the causal<br />

relationship grid. The key determinant of the overall causal<br />

conclusion is highly dependent on the scalable conclusions <strong>for</strong><br />

both the toxicological and epidemiological evidence. There<strong>for</strong>e,<br />

we will present the detailed rationale <strong>for</strong> each of these and<br />

discuss the required assumptions and sources of uncertainties<br />

in interpreting these placements. Following this method, the<br />

evidence enters the “Likely” quadrant <strong>for</strong> NPC, whereas <strong>for</strong> ML<br />

the evidence enters the “Unlikely” quadrant.<br />

M2-E.5 Bolger, PM*; Ezendam, J; Exponent, Washington DC;<br />

National Institute <strong>for</strong> Public Health and the Environment,<br />

Bilthoven, The Netherlands; pmbolger33@gmail.com<br />

Peanut allergen: Global Burden of Disease<br />

A systematic literature review of peanut allergy was per<strong>for</strong>med<br />

within the framework of the Foodborne Epidemiology<br />

Reference Group (FERG) of the World Health Organization<br />

(WHO) that is tasked with estimating the global burden of<br />

disease (BOD) <strong>for</strong> food borne diseases. The symptoms of peanut<br />

allergy vary from mild to severe, from swollen lips, shortness of<br />

breath to anaphylactic shock, which is potentially fatal. The<br />

most important parameters were found to be the number of<br />

people who suffer from a peanut allergy and the impact it has<br />

on their quality of life. BOD is a measure that quantifies the<br />

consequences of a disease by combining the loss of health from<br />

impaired quality of life and premature mortality. The<br />

prevalence of peanut allergy in Western countries is 0.5 to 1.5<br />

per cent of the population; however, there is a lack of<br />

prevalence data from developing countries. Geographical<br />

differences in prevalence appear to exist, since peanut allergy<br />

is uncommon in Turkey and Israel. Symptoms of the allergy are<br />

induced when individuals with a peanut allergy eat products<br />

that contain peanuts. Although they can be severe, the<br />

symptoms are usually short-lasting. Consequently, they will not<br />

have a large impact on BOD. The number of people who die due<br />

to a peanut allergy is low which also has a limited impact on<br />

BOD. The quality of life of people with a peanut allergy can be<br />

significantly impaired, primarily because they are anxious<br />

about accidentally eating products that contain peanut. This<br />

impairment of quality of life is important in deriving an<br />

estimate of the BOD.<br />

December 8-11, 2013 - Baltimore, MD

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