Abstracts (PDF file, 1.8MB) - Society for Risk Analysis
Abstracts (PDF file, 1.8MB) - Society for Risk Analysis
Abstracts (PDF file, 1.8MB) - Society for Risk Analysis
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SRA 2013 Annual Meeting <strong>Abstracts</strong><br />
M4-E.2 Boelter, FW*; Xia, Y; Persky, JD; ENVIRON<br />
International; fboelter@environcorp.com<br />
Cumulative Exposures to Asbestos Fibers from Dropped<br />
Ceiling Installation and Maintenance<br />
Dropped ceilings began around 1940s to be used in commercial<br />
and to a lesser degree residential construction <strong>for</strong> better<br />
acoustics, modern appearance, reduction of heating and<br />
lighting costs, and compatibility with then-new suspended<br />
fluorescent lighting. Several fatal fires including the 1958 Our<br />
Lady of the Angels fire in Chicago in which combustible<br />
building materials including acoustic tiles were accused of<br />
costing loss of life, hastened the inclusion of fireproof asbestos<br />
in interior building materials until the mid to late 1970's. We<br />
developed an algorithm <strong>for</strong> the reconstruction of exposures to<br />
airborne asbestos fibers resulting from ceiling tile activities and<br />
implemented the algorithm using hypothetical work histories<br />
<strong>for</strong> five categories of people – specialty construction<br />
contractors, general building contractors, Do-It-Yourself<br />
nonprofessionals (DIYer), maintenance trades, and bystanders.<br />
We present new exposure data obtained through two field<br />
studies on asbestos-containing ceiling tiles removal and<br />
replacement and one chamber study involving cutting and<br />
installing such tiles. These data, coupled with professional<br />
judgment and mathematical modeling (Bayesian decision<br />
analysis and stochastic simulation), lead to the estimations of 8<br />
h time-weighted average (TWA) as well as 1-year and 10-year<br />
cumulative exposures to asbestos fibers from working with<br />
asbestos-containing ceiling tiles. Our results estimate mean<br />
1-year cumulative exposure expressed as f/cc-years to be 0.007<br />
<strong>for</strong> specialty construction contractors, 0.0004 <strong>for</strong> general<br />
building contractors, 0.00008 <strong>for</strong> Do-It-Yourself<br />
nonprofessionals, 0.004 <strong>for</strong> maintenance trades, and 0.0004 <strong>for</strong><br />
bystanders. The distributions of 8 h TWA dust and asbestos<br />
fiber exposures estimated <strong>for</strong> the five worker categories are<br />
compared to historical exposure data, while the cumulative<br />
exposure estimates are used to evaluate health risks. None of<br />
the five categories of workers receive a cumulative exposure<br />
(dose) that would significantly increase their risk <strong>for</strong> disease<br />
development.<br />
T2-H.1 Boerman, D*; Gallagher, M; Headquarters, U.S. Air<br />
Force; douglas.boerman@pentagon.af.mil<br />
U.S. Air Force <strong>Risk</strong> Assessment Framework<br />
The Headquarters of the United States Air Force has adopted<br />
major components of the Chairman of the Joint Chiefs of Staff's<br />
<strong>Risk</strong> Assessment System to develop a risk-based decision<br />
support approach to in<strong>for</strong>m major decisions, especially with<br />
regard to logistics. The major advantages of using the<br />
Chairman's system are improved clarity in internal Air Force<br />
decisions and improved risk communication between the Air<br />
Force and the Joint Staff. Use of a mature, rigorous process<br />
improves both identification of risk origin and credibility in<br />
communicating risk in<strong>for</strong>mation. This transition to a <strong>Risk</strong><br />
Assessment Framework is still underway and lessons learned in<br />
implementing a new risk approach within a complex<br />
government organization will benefit risk practioners in and out<br />
of government<br />
W4-B.3 Boffetta, P*; Mundt, KA; Mundt, DJ; Checkoway, H;<br />
Swenberg, J; Adami, H-O; Icahn School of Medicine at Mount<br />
Sinai, ENVIRON International Corporation University of<br />
washington, Seattle, University of North Carolina at Chapel<br />
Hill, Harvard University School of Public Health;<br />
paolo.boffetta@i-pri.org<br />
Integrating toxicological & epidemiological evidence of<br />
carcinogenicity: Application of Epid-Tox framework <strong>for</strong><br />
evaluating relationships between <strong>for</strong>maldehyde &<br />
nasopharyngeal cancer & myeloid leukemia<br />
Substantial scientific evidence is available to evaluate the<br />
carcinogenicity of <strong>for</strong>maldehyde. Although several evaluations<br />
have been conducted, none has <strong>for</strong>mally integrated<br />
toxicological and epidemiological evidence. Applying the<br />
Epid-Tox Framework <strong>for</strong> systematically combining toxicological<br />
and epidemiological evidence, as described by Adami et al.<br />
(2011), we present causal inference grids <strong>for</strong> the association<br />
between <strong>for</strong>maldehyde exposure and risks <strong>for</strong> nasopharyngeal<br />
cancer (NPC) and myeloid leukemia (ML). Separate grids are<br />
necessary because of the likely different modes of action, as<br />
well as the different epidemiological evidence <strong>for</strong> these two<br />
malignancies. For each grid, we applied the following steps<br />
separately <strong>for</strong> the toxicological and epidemiological evidence:<br />
1) we assessed the quality of primary research studies and<br />
categorize them as “acceptable”, “supplementary” or<br />
“unacceptable”; 2) we per<strong>for</strong>med a weight of evidence<br />
evaluation; and 3) we assigned a scalable conclusion regarding<br />
the strength or plausibility of the evidence, stated in terms of<br />
“evidence of effect” or “evidence of an absence of effect”. The<br />
scalable conclusions are simultaneously placed on the causal<br />
relationship grid. The key determinant of the overall causal<br />
conclusion is highly dependent on the scalable conclusions <strong>for</strong><br />
both the toxicological and epidemiological evidence. There<strong>for</strong>e,<br />
we will present the detailed rationale <strong>for</strong> each of these and<br />
discuss the required assumptions and sources of uncertainties<br />
in interpreting these placements. Following this method, the<br />
evidence enters the “Likely” quadrant <strong>for</strong> NPC, whereas <strong>for</strong> ML<br />
the evidence enters the “Unlikely” quadrant.<br />
M2-E.5 Bolger, PM*; Ezendam, J; Exponent, Washington DC;<br />
National Institute <strong>for</strong> Public Health and the Environment,<br />
Bilthoven, The Netherlands; pmbolger33@gmail.com<br />
Peanut allergen: Global Burden of Disease<br />
A systematic literature review of peanut allergy was per<strong>for</strong>med<br />
within the framework of the Foodborne Epidemiology<br />
Reference Group (FERG) of the World Health Organization<br />
(WHO) that is tasked with estimating the global burden of<br />
disease (BOD) <strong>for</strong> food borne diseases. The symptoms of peanut<br />
allergy vary from mild to severe, from swollen lips, shortness of<br />
breath to anaphylactic shock, which is potentially fatal. The<br />
most important parameters were found to be the number of<br />
people who suffer from a peanut allergy and the impact it has<br />
on their quality of life. BOD is a measure that quantifies the<br />
consequences of a disease by combining the loss of health from<br />
impaired quality of life and premature mortality. The<br />
prevalence of peanut allergy in Western countries is 0.5 to 1.5<br />
per cent of the population; however, there is a lack of<br />
prevalence data from developing countries. Geographical<br />
differences in prevalence appear to exist, since peanut allergy<br />
is uncommon in Turkey and Israel. Symptoms of the allergy are<br />
induced when individuals with a peanut allergy eat products<br />
that contain peanuts. Although they can be severe, the<br />
symptoms are usually short-lasting. Consequently, they will not<br />
have a large impact on BOD. The number of people who die due<br />
to a peanut allergy is low which also has a limited impact on<br />
BOD. The quality of life of people with a peanut allergy can be<br />
significantly impaired, primarily because they are anxious<br />
about accidentally eating products that contain peanut. This<br />
impairment of quality of life is important in deriving an<br />
estimate of the BOD.<br />
December 8-11, 2013 - Baltimore, MD