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Table II.
Effective dose, upper-bound estimate of relative risk and unit risk of carcinogenicity due
to human beryllium exposure via inhalation (US EPA, 1992).
Beryllium concentration
in workplace (µg/m 3 )
Fraction of
lifetime
Effective dose
(µg/m 3 )
95% upper-bound
estimate of relative risk
Unit risk/
(µg/m 3 )
100 1.00 21.92 1.98 1.61E-3
2.09 1.79E-3
0.25 5.48 1.98 6.44E-3
2.09 7.16E-3
1000 1.00 219.18 1.98 1.61E-4
2.09 1.79E-4
0.25 54.79 1.98 6.44E-4
2.09 7.16E-4
V. REFERENCES
Bayliss DL and Wagoner JK. 1977. Bronchogenic cancer and cardio-respiratory disease mortality
among white males employed in a beryllium production facility. OSHA Beryllium Hearing, Exhibit 13.F.
Groth DH, Kommineni C, and Mackay GR. 1980. Carcinogenicity of beryllium hydroxide and alloys.
Environ Res 21:63-84.
Hazardous Substance Data Bank (HSDB) 1994. National Library of Medicine, Bethesda MD (CD-
ROM Version). Micromedix, Inc., Denver CO, Edition 22.
Ishinishi N, Mizunoe M, Inamasu T and Hisanga A. 1980. Experimental study on carcinogenicity of
beryllium oxide and arsenic trioxide to the lung of rats by an intratracheal instillation. Fukuoka Igaku
Zasshi 71:19-26.
MacMahon B. 1977. Evaluation of epidemiological materials. January 10, 1978. Brush Wellman,
Cleveland, OH. OSHA Beryllium Hearings: 5.
MacMahon B. 1978. Comment on recent post-hearing submissions. February 9, 1979. OSHA
Beryllium Hearings, Docket No. H005.
Mancuso TF. 1970. Relation of duration of employment and prior respiratory illness to respiratory
cancer among beryllium workers. Environ Res 3:251-275.
Mancuso TF. 1979. Occupational lung cancer among beryllium workers in dusts and disease. In:
Proceedings of the Conference on Occupational Exposure to Fibrous and Particulate Dust and
Their Extension into the Environment. Lemen R and Dement J, eds., Pathotox Publishers, Inc..
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