home edit2 whole TSD November 2002 PDF format - OEHHA

1,3-PROPANE SULTONE
CAS No: 1120-71-4
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 122.1
Boiling point
180°C at 30 mm Hg
Melting point 31°C
Vapor pressure
not available
Air concentration conversion 1 ppm = 5.01 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 6.9 E-4 (µg/m 3 ) -1
Slope Factor: 2.4 E+0 (mg/kg-day) -1
[Male rat cerebellar malignant glioma tumor data (Ulland et al., 1971; Weisburger et al.,
1981), contained in Gold et al. database (1984), expedited Proposition 65 methodology
(Cal/EPA, 1992)]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of 1,3-propane sultone on humans are known to exist.
Animal Studies
Several studies exist on the potential carcinogenic effects of 1,3-propane sultone in animals. These
studies have been reviewed by IARC (1974).
BD rats (12/group, sex unspecified) were given 30 mg/kg body weight 1,3-propane sultone as a 3%
aqueous solution weekly by gavage (Druckrey et al., 1970). Four of 10 survivors developed tumors
between days 248 and 377; tumors noted were 1 glial-mesodermal mixed tumor, 1 advential cell
sarcoma of the brain, 1 nephroblastoma and 1 subcutaneous spindle cell sarcoma.
Local sarcomas resulting in mortality were induced in all of 18 BD rats given weekly subcutaneous
injections of 15 mg/kg 1,3-propane sultone in water (total dose 225 mg/kg) between 208 and 387
days. Additionally, single subcutaneous injections of 30 or 100 mg/kg produced local sarcomas at the
injection site resulting in mortality in 12/18 animals and 18/18 animals, respectively (Druckrey et al.,
1970). In the same study, BD rats were given 1,3-propane sultone as a 1% solution in arachis oil by
subcutaneous injection weekly at doses of 15 or 30 mg/kg. Mortality resulted from local sarcomas
which developed (myosarcomas and fibrosarcomas) at the site of injection (7/12 and 11/11 rats in the
500