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2, 4-DIAMINOANISOLE
CAS No: 615-05-4
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 138.17
Boiling point
not available
Melting point 67-68 °C
Vapor pressure
not available
Air concentration conversion 1 ppm = 5.651 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 6.6 E-6 (µg/m 3 ) -1
Slope Factor: 2.3 E-2 (mg/kg-day) -1
[Male rat thyroid tumors (NCI, 1978), contained in Gold et al. (1984) database, expedited
Proposition 65 methodology (Cal/EPA, 1992), with cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of 2,4-diaminoanisole in humans are known to exist.
Animal Studies
Male and female Fischer 344 (F344) rats and B6C3F 1 mice were fed diets containing 2,4-
diaminoanisole (DAA) sulfate (NCI, 1978). Mice were fed diets containing 1200 or 2400 mg/kg DAA
sulfate for 78 weeks and were observed for an additional 18-19 weeks. Rats were fed diets containing
5000 mg/kg DAA sulfate for 78 weeks, or diet containing 1250 mg/kg DAA sulfate for 10 weeks, then
1200 mg/kg diet for 68 weeks, followed by a 29 week observation period. Matched control groups
were provided for each dose group. Group sizes were 50 animals/sex/species/group with the exception
of the male rat high-dose control group (49 animals). Mortality of control and treated rats and mice
were similar by the end of the study. Significantly increased incidences of thyroid tumors were seen in
both mice (males - follicular cell adenomas; females - follicular cell adenomas, carcinomas) and rats
(follicular cell adenocarcinomas, carcinomas, papillary adenocarcinomas and cystadenocarcinomas).
Increased skin tumor incidences (squamous-cell carcinomas, basal-cell carcinomas, sebaceous
adenocarcinomas) were observed in male rats. Male and female rats both had increased incidences of
preputial or clitoral gland adenomas, papillomas or carcinomas and Zymbal gland tumors (males -
squamous cell carcinomas, sebaceous adenocarcinomas; females - sebaceous adenocarcinomas).
Tumor incidence data is listed in Table 1.
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