home edit2 whole TSD November 2002 PDF format - OEHHA

Table 1.
Experimental design for carcinogenicity bioassay of cupferron using male and female
Fischer 344 (F344) rats and B6C3F 1 mice (NCI, 1978)
Sex/species Group Cupferron
concentration
(%)
Experiment duration
(weeks)
Time-weighted
average
concentration 1
treatment
period
observation
period
male rats control 0 0 110
low dose 0.15 78 26
high dose 0.3 78 19
female rats control 0 0 110
low dose 0.15 78 28
high dose 0.3 78 28
male, female mice control 0 98 0
low dose 0.3 35 0.2
0.1 43 18
high dose 0.6 35 0.4
0.2 43 17
1. Time-weighted concentration = ∑ (concentration × weeks received )
∑ (weeks receiving chemical)
Table 2.
Cupferron-induced hemangiosarcoma incidence in male and female F344 rats and
B6C3F 1 mice (NCI, 1978)
Sex/species Dose group Average dose 1
(mg/kg-day)
Tumor incidence 2
Male rat control 0 0/50
low dose 45 38/50
high dose 96.5 35/49
Female rat control 0 0/50
low dose 55.2 28/50
high dose 110 37/50
Male mouse control 0 1/50
low dose 185 3/50
high dose 374 7/50
Female mouse control 0 1/50
low dose 200 5/50
high dose 405 6/50
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