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p-NITROSODIPHENYLAMINE
CAS No: 156-10-5
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 198.24
Boiling point
not available
Melting point 144-145 °C
Vapor pressure
not available
Air concentration conversion 1 ppm = 8.1 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 6.3 E-6 (µg/m 3 ) -1
Slope Factor: 2.2 E-2 (mg/kg-day) -1
[Male rat liver tumor data (NCI, 1979), contained in Gold et al. (1984) database, expedited
Proposition 65 methodology (Cal/EPA, 1992), with cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of p-nitrosodiphenylamine in humans are known to
exist.
Animal Studies
Male and female Fischer 344 rats and B6C3F 1 mice were fed diets containing technical grade p-
nitrosodiphenylamine (73% active material, 25% water, unspecified impurities). Rats were fed diets
containing 2500 or 5000 mg/kg diet p-nitrosodiphenylamine for 78 weeks, followed by a 27 week
observation period. Mice were fed diets containing either 5000 mg/kg diet p-nitrosodiphenylamine for
40 weeks, then 2500 mg/kg diet for 17 weeks, or 10000 mg/kg diet for 40 weeks, followed by control
diet for 7 weeks, then 5000 mg/kg for 10 weeks. Both dose groups were then maintained on control
diet for an additional 35 weeks. Treatment groups consisted of 50 animals/sex/species/group; matched
control groups consisted of 20 animals/sex/species and were kept under observation for 105 and 92
weeks for rats and mice, respectively. Rat survival was 90, 86 and 92% for males and 85, 84 and 92%
for females in the control, low-dose and high-dose groups, respectively. Mouse survival was 85, 88
and 60% for males and 90, 84 and 52% for females in the control, low-dose and high-dose groups,
respectively. Significant increases in the incidence of liver tumors (neoplastic nodules, hepatocellular
adenomas and carcinomas) was noted in treated male mice and rats. Tumor incidence data is listed in
Table 1.
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