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2,4-DINITROTOLUENE
CAS No: 121-14-2
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 182.14
Boiling point 300°C
Melting point 71°C
Vapor pressure 0.00014 mm Hg @ 25°C
Air concentration conversion 1 ppm = 7.4 mg/m 3 @ 25°C
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 8.9 E-5 (µg/m 3 ) -1
Slope Factor: 3.1 E-1 (mg/kg-day) -1
[calculated from a potency factor derived by US EPA (1987) and adopted by CDHS (see
Final Statement of Reasons)]
III.
CARCINOGENIC EFFECTS
Human Studies
No data are available addressing the carcinogenicity of 2,4-dinitrotoluene (2,4-DNT) in humans.
Animal Studies
Lee et al. (1978) exposed male and female CD rats to practical grade 2,4-DNT in feed at
concentrations of 0, 15, 100, and 700 ppm for 720 days. Animals were sacrificed at 750 days.
Decreased weight gain and lifespan were observed among animals in the highest treatment group.
Noncancer toxic effects observed included toxic anemia and aspermatogenesis. Tumors observed
included fibromas of the connective tissue of male rats and fibroadenoma of the mammary gland of
female rats. The incidence data for liver and mammary tumors in female rats are presented in Table 1.
Significantly increased incidence was found in the highest dose group for liver tumors (p = 4 × 10 -4 ;
Fisher’s exact test), mammary gland tumors (p = 1.75 × 10 -4 ), and combined mammary gland and
liver tumors (p = 7 × 10 -5 ). Mammary tumor incidence among male rats was 1/37, 0/37, 0/29, and
17/23 in the 0, 15, 100, and 700 ppm 2,4-DNT dose groups, respectively. Only the highest dose
group showed significantly increased tumor incidence (p = 4 × 10 -9 ).
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