home edit2 whole TSD November 2002 PDF format - OEHHA

Table 4:
Values from Unit Risk for Diesel Exhaust from Using Hazard Slope on Exposure
Measure in California Life-Table. Garshick et al. (1987a, 1988) Studies of U.S.
Railroad Workers.
MLE
q1 (µg/m³) -1
95% UCL
I. Case-Control study (1987a) using published slope coefficient for hazard on years of exposure to
diesel exhaust (Section 7.3.3)
A. Adapted to ramp (1,50) pattern of exposure 1.4 × 10 -3 2.4 × 10 -3
B. Adapted to roof (2,40) pattern of exposure 1.1 × 10 -3 1.8 × 10 -3
C. Adapted to roof (3,50) pattern of exposure 6.2 × 10 -4 1.0 × 10 -3
D. Adapted to roof (3,80) pattern of exposure 3.9 × 10 -4 6.6 × 10 -4
E. Adapted to roof (10,50) pattern of exposure 2.1 × 10 -4 3.6 × 10 -4
II. Cohort study (1988) using individual data to obtain a slope
for hazard on years of exposure to diesel exhaust (Section 7.3.4)
Continuous covariates: (attained age and calendar year)
or (age-at-start-of study and calendar year)
A. Adapted to ramp (1,50) pattern of exposure 1.3 × 10 -3 1.8 × 10 -3
B. Adapted to roof (2,40) pattern of exposure 9.9 × 10 -4 1.4 × 10 -3
B. Adapted to roof (3,50) pattern of exposure 5.7 × 10 -4 8.2 × 10 -4
D. Adapted to roof (3,80) pattern of exposure 3.6 × 10 -4 5.1 × 10 -4
E. Adapted to roof (10,50) pattern of exposure 1.9 × 10 -4 2.8 × 10 -4
III. Cohort study (1988) applying time varying concentrations to
individual data to obtain a slope of hazard on exposure
(from Appendix D)
A. Ramp (1,50) pattern of exposure
1. General multiplicative model with age-at-start-of-study
and U.S. rates as categorical covariates 1.2 × 10 -3 1.9 × 10 -3
2. 6th/7-stage model with age-at-start-of study as
categorical covariate 2.4 × 10 -4 3.8 × 10 -4
B. Roof (3,50) pattern of exposure
1. General multiplicative model with age-at-start-of-study
and U.S. rates as categorical covariates 5.1 × 10 -4 7.2 × 10 -4
2. 6th/7-stage model with age-at-start-of-study
as categorical covariate 8.1 × 10 -5 1.3 × 10 -4
3. 7th/7-stage model with age-at-start-of-study as
categorical covariate 1.0 × 10 -4 1.5 × 10 -4
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