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Table 1:
Tumor induction in Fischer 344 rats and B6C3F 1 mice by dietary administration
of 2,4-diaminoanisole (NCI, 1978)
Sex/species Dose group Average Dose 1
(mg/kg-day)
Tumor type Tumor Incidence 2
Male mouse control 0 thyroid 1/100
low dose 116 0/50
high dose 234 11/50
Female mice control 0 thyroid 0/100
low dose 126 0/50
high dose 253 8/50
Male rats control 0 thyroid 2/99
low dose 35.2 2/50
high dose 146 17/50
control 0 preputial gland 0/99
low dose 35.2 2/50
high dose 146 8/50
control 0 skin 0/99
low dose 35.2 2/50
high dose 146 9/50
control 0 Zymbal gland 0/99
low dose 35.2 1/50
high dose 146 6/50
Female rats control 0 thyroid 3/100
low dose 44 1/50
high dose 182 10/50
control 0 clitoral gland 3/100
low dose 44 5/50
high dose 182 8/50
control 0 Zymbal gland 0/100
low dose 44 0/50
high dose 182 4/50
1. Doses reported by Gold et al., 1984.
2. Tumor incidences reported by Gold et al., 1984.
Diets containing 2,4-diaminoanisole at concentrations of 0, 1200, 2400 or 5000 mg/kg diet were fed to
female F344 rats (40 - 60/group) for up to 82-86 weeks (Evarts and Brown, 1980). An additional 15
rats were fed diet containing 5000 mg/kg diet for 10 weeks, then fed control diet and observed for up
to 87 weeks. Thyroid tumor incidences (follicular-cell adenomas or carcinomas or C cell carcinomas)
were 1/37 in controls, 2/47 in the low-dose group, 3/33 in the mid-dose group and 31/40 in the high-
230