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TOLUENE DIISOCYANATE
CAS No: 26471-62-5
2,4-TOLUENE DIISOCYANATE
CAS No: 584-84-9
2,6-TOLUENE DIISOCYANATE
CAS No: 91-08-7
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 174.15
Boiling point
251°C at 760 mm Hg
Freezing point 22°C (pure toluene-2,4-diisocyanate (IARC, 1985);
7.2°C (pure toluene-2,6-diisocyanate (IARC, 1985)
Vapor pressure 0.01 mm Hg at 20°C
Air concentration conversion 1 ppm = 7.12 mg/m 3 (IARC, 1985)
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 1.1 E-5 (µg/m 3 ) -1
Slope Factor: 3.9 E-2 (mg/kg-day) -1
[Male rat subcutaneous fibroma/fibrosarcoma tumor data (NTP, 1986) contained in Gold et al.
database (1990), expedited Proposition 65 methodology (Cal/EPA, 1992)]
III.
CARCINOGENIC EFFECTS
Human Studies
A case report reviewed by IARC (1985) described a 47-year old nonsmoking spray painter with a lung
adenocarcinoma who had been exposed to TDI and 4,4'-methylenediphenyl diisocyanate for 15 years
and had a 10-year history of lung disease thought to be caused by isocyanate exposure (Mortillaro and
Schiavon, 1982).
Hagmar et al. (1993) performed a cohort based case-referent study to assess any potential cancer risk
associated with occupational exposure to TDI or methylene diphenyldiisocyanate. The subjects were
7023 workers employed during the period 1958 to 1987 in nine Swedish polyurethane foam
manufacturing plants. Odds ratios were adjusted with respect to matching factors (age at risk, calendar
year at risk, sex, and plant), calculated from a conditional logistic regression model. An association was
found between intermediate/high exposure to isocyanates and prostate cancer (OR 2.96, 90%
confidence interval (90% CI) 0.45-19.4); however, this association was not statistically significant. An
association between isocyanate exposure and colon cancer (OR 3.25, 90% CI 0.5 - 21.3) was also not
statistically significant. Study limitations included a small number of subjects (102 controls, 155 in the
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