home edit2 whole TSD November 2002 PDF format - OEHHA

RAAC recommendation
An internal Cal/EPA working group should be
established whose specific charge is to insure
agency-wide consistency and harmonization.
Cal/EPA should develop a formalized program for
peer review.
Cal/EPA should seek early input into the risk
assessment process from risk managers and from
external stakeholders. The Agency should identify
effective and efficient mechanisms for participation
by the general public and interested stakeholders
and apply these throughout the Agency.
The Committee recommends that Cal/EPA consider
an approach in conducting chemical risk
assessments that balances the level of effort and
resources with the importance of the risk
assessment.
“Cal/EPA should endeavor to develop future risk
assessments in concert with US EPA, especially
for high volume and/or high risk compounds.
Before Cal/EPA conducts an independent risk
assessment for a substance, it should first review
any existing US EPA risk assessment.”
TSD implementation
Cal/EPA-generated cancer potency values
contained in the TSD have been reviewed by the
Standards and Criteria Work Group, an internal
Cal/EPA working group, for consistency and
harmonization. The cancer potency factors in the
TSD are the same as those in the Standards and
Criteria Workgroup’s document entitled “Criteria
for Carcinogens”.
The TSD will be peer reviewed by an advisory
committee of scientists from outside State
government (the Air Resources Board’s Scientific
Review Panel) using a formalized process.
The TSD has been reviewed by Cal/EPA risk
assessors and the Air Quality Management and Air
Pollution Control Districts and will be distributed
to interested parties, including external
stakeholders, for public comment. The Cal/EPA
cancer potency factors have already undergone
stakeholder, public and peer review in their
respective programs prior to their inclusion in this
document.
The TSD has optimized use of OEHHA resources
by developing a decision hierarchy which permits
utilization of previously developed Cal/EPA and
US EPA cancer potency factors.
The TSD has incorporated US EPA cancer
potency factors listed in IRIS (as shown in the
Unit Risk and Cancer Potency Factors Table of
the TSD) where appropriate. In other cases
California-developed information has been used if
it supersedes US EPA information, or addresses
compounds still awaiting consideration by US
EPA.
19