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2, 4-DIAMINOTOLUENE
CAS No: 95-80-7
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 122.17
Boiling point 292 °C
Melting point 99 °C
Vapor pressure
not available
Air concentration conversion 1 ppm = 4.997 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 1.1 E-3 (µg/m 3 ) -1
Slope Factor: 4.0 E+0 (mg/kg-day) -1
[Female rat mammary gland tumors (NCI, 1978), contained in Gold et al. database (1984),
expedited Proposition 65 methodology (Cal/EPA, 1992), cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the carcinogenic potential of 2,4-diaminotoluene in humans are known to exist.
Animal Studies
IARC (1978) reviewed a study by Umeda (1955) in which 20 rats of mixed strain and sex were
injected subcutaneously with 0.5 ml of a 0.4% solution of 2,4-diaminotoluene at weekly intervals. No
tumor induction was noted in 11 rats that died in the first 8 months of the study. All 9 surviving rats,
which received 29-44 weekly injections, developed subcutaneous sarcomas. No concurrent control
group was included in this study; however, another group of 12 rats exposed to 11 subcutaneous
injections of xanthene in propylene glycol over 10 months did not develop local sarcomas.
Male Wistar rats were fed diets containing 0, 0.06% or 0.1% 2,4-diaminotoluene for 30-36 weeks (12
animals/treatment group, 6 animals/control group) (Ito et al., 1969). Exposure to 2,4-diaminotoluene
caused an increased incidence of hepatocellular carcinomas in the treated animals (0/6, 7/11, and 9/9 in
the control, low-dose and high-dose groups, respectively).
Male and female Fischer 344 (F344) and B6C3F 1 mice were fed diets containing 2,4-diaminotoluene
(NCI, 1979). Treatment group sizes were 50 animals/sex/species/group; matched control group sizes
were 20 animals/sex/species/group. The study design is outlined in Table 1. Male and female rat lowand
high-dose levels were reduced after 40 weeks.
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