home edit2 whole TSD November 2002 PDF format - OEHHA

N-NITROSOPIPERIDINE
CAS No: 100-75-4
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 114.15
Boiling point
217 °C (@ 721 mmHg)
Melting point
not available
Vapor pressure
not available
Air concentration conversion 1 ppm = 4.7 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 2.7 E-3 (µg/m 3 ) -1
Slope Factor: 9.4 E+0 (mg/kg-day) -1
[Rat liver tumors (Eisenbrand et al., 1980), contained in Gold et al. (1987) database, expedited
Proposition 65 methodology (Cal/EPA, 1992), with cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of N-nitrosopiperidine in humans are known to exist.
Animal Studies
Takayama (1969) fed 33 male ICR mice diets containing 50 mg/kg N-nitrosopiperidine for a period of
12 months; a 30 animal untreated control group was included. An increased incidence of forestomach
(squamous cell carcinoma), liver and lung (adenomas) tumors were observed in treated animals when
compared to controls. Tumor incidence data is listed in Table 1.
Table 1. N-nitrosopiperidine-induced tumor incidence in male ICR mice (Takayama, 1969)
Dose group Average dose 1
Tumor type Tumor incidence 2
(mg/kg-day)
controls 0 forestomach 0/30
liver 0/30
lung 2/30
treated 6 forestomach 18/33
liver 6/33
lung 10/33
1. Doses as reported by Gold et al. (1984).
2. Tumor incidences as reported by Gold et al. (1984).
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