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ANILINE
CAS No: 62-53-3
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 93.12
Boiling point
184-186°C
Melting point
-6.3°C
Vapor pressure 0.67 mm Hg at 25°C
Air concentration conversion 1 ppm = 3.82 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 1.6 E-6 (µg/m 3 ) -1
Slope Factor: 5.7 E-3 (mg/kg-day) -1
[Derived from a cancer potency factor calculated by US EPA/IRIS (1990, 1994) from male rat
primary splenic sarcoma incidence data (CIIT, 1982) using a linearized multistage procedure,
extra risk; adopted by CDHS/RCHAS (1990)]
III.
CARCINOGENIC EFFECTS
Human Studies
US EPA (1994) reviewed a study that examined the occurrence of bladder tumors in British workers in
the chemical dye industry (Case et al., 1954). A group of 4622 men employed for more than 6 months
in the United Kingdom chemical industry during the period 1910-1952 were studied. In a subgroup of
1233 men exposed solely to aniline, one death from bladder cancer was observed compared to 0.83
expected from English/Welsh male mortality data. Among the entire group (who had generally been
exposed to a number of aromatic amines including napthylamine, benzidine, auramine and aniline; no
detailed exposure information was available), 127 deaths from bladder cancer were observed
compared to 4.1 expected. The authors concluded that the data provided insufficient evidence to
suggest that aniline itself causes bladder tumors.
Animal Studies
Forty-three male and female Osborne-Mendel rats were fed diets containing 330 mg/kg aniline
hydrochloride for up to 1032 days (White et al., 1948). Hepatomas and splenic sarcomas were noted
in 4 and 3 animals, respectively. No control group was included in the study; however, the authors
claimed that liver and spleen tumors were rare in the rat strain used in the study.
IARC (1982) reviewed a study by Druckrey (1950) in which rats (random bred, sex unspecified) were
exposed to aniline hydrochloride in drinking water (22 mg/rat/day) over their lifetime. Mortality was
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