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Chemical Exposure Route Study Type Unit Risk Slope Factor Animal Unit Animal Slope (µg/m 3 ) -1 (mg/kg-day) -1 Risk Factor (µg/m 3 ) -1 (mg/kg-day) -1 p-Chloro-o-toluidine D A 7.7 E-5 2.7 E-1 Chromium (hexavalent) (inhalation) I H 1.5 E-1 5.1 E+2 NA (oral) DW A 4.2 E-1 Chrysene BaP (inhalation) 1.1 E-5 3.9 E-2 (oral) 1.2 E-1 Creosote I A * * p-Cresidine D A 4.3 E-5 1.5 E-1 Cupferron D A 6.3 E-5 2.2 E-1 2,4-Diaminoanisole D A 6.6 E-6 2.3 E-2 2,4-Diaminotoluene D A 1.1 E-3 4.0 E+0 Dibenz[a,h]acridine BaP (inhalation) 1.1 E-4 3.9 E-1 Footnotes # [100 PCM fibers/m 3 ] -1 ; see Appendix D * can be calculated using PEF factors contained in the benzo[a]pyrene TAC document A see Appendix A BaP see benzo[a]pyrene TAC document; calculated from unit risk/cancer potency factors for BaP using PEF factors D Listed by ARB as “Particulate Matter from Diesel-Fueled Engines”; Scientific Review Panel unit risk “reasonable estimate” = 3.0 E-4 (µg/m 3 ) -1 . Range of unit risks in TAC document was 1.3 E-4 – 2.4 E-3 (µg/m 3 ) -1 . P See chemical summary for risk categorization Exposure Routes D = diet; DW = drinking water; G = gavage; I = inhalation; O = other oral route Study Type A = animal; H = human Document Source bold type = TAC document (oral) 1.2 E+0 Dibenz[a,j]acridine BaP 1.1 E-4 3.9 E-1 1.2 E+0 Dibenz[a,h]anthracene BaP 1.2 E-3 4.1 E+0 Dibenzo[a,e]pyrene BaP (inhalation) 1.1 E-3 3.9 E+0 (oral) 1.2 E+1 Dibenzo[a,h]pyrene BaP (inhalation) 1.1 E-2 3.9 E+1 (oral) 1.2 E+2 Dibenzo[a,i]pyrene BaP (inhalation) 1.1 E-2 3.9 E+1 (oral) 1.2 E+2 Dibenzo[a,l]pyrene BaP (inhalation) 1.1 E-2 3.9 E+1 (oral) 1.2 E+2 7H-Dibenzo[c,g]carbazole BaP (inhalation) 1.1 E-3 3.9 E+0 (oral) 1.2 E+1 1,2-Dibromo-3-chloropropane D A 2.0 E-3 7.0 E+0 Animal Unit Risk, Slope Factors C = obtained from Cal/EPA or CDHS risk assessment; I = obtained from US EPA IRIS listing 591
Chemical Exposure Route Study Type Unit Risk Slope Factor Animal Unit Animal Slope (µg/m 3 ) -1 (mg/kg-day) -1 Risk Factor (µg/m 3 ) -1 (mg/kg-day) -1 1,4-Dichlorobenzene G A 1.1 E-5 4.0 E-2 3,3'-Dichlorobenzidine D A 3.4 E-4 1.2 E+0 1,1-Dichloroethane G A 1.6 E-6 5.7 E-3 Diesel exhaust I H 3.0 E-4 D 1.1 E+0 Diethylhexylphthalate D A 2.4 E-6 8.4 E-3 p-Dimethylaminoazobenzene D A 1.3 E-3 4.6 E+0 7,12-Dimethylbenz[a]anthracene BaP (inhalation) 7.1 E-2 2.5 E+2 1,6-Dinitropyrene BaP (inhalation) 1.1 E-2 3.9 E+1 (oral) 1.2 E+2 1,8-Dinitropyrene BaP (inhalation) 1.1 E-3 3.9 E+0 (oral) 1.2 E+1 2,4-Dinitrotoluene D A 8.9 E-5 3.1 E-1 1,4-Dioxane DW A 7.7 E-6 2.7 E-2 Epichlorohydrin DW A 2.3 E-5 8.0 E-2 Ethylene dibromide G A 7.1 E-5 2.5 E-1 Ethylene dichloride G A 2.1 E-5 7.2 E-2 Ethylene oxide I A 8.8 E-5 3.1 E-1 Ethylene thiourea D A 1.3 E-5 4.5 E-2 Formaldehyde I A 6.0 E-6 2.1 E-2 Hexachlorobenzene D A 5.1 E-4 1.8 E+0 Hexachlorocyclohexanes (technical grade) D A 1.1 E-3 4.0 E+0 Hydrazine (inhalation) I A 4.9 E-3 1.7 E+1 (oral) G A 3.0 E+0 Indeno[1,2,3-cd]pyrene BaP (inhalation) 1.1 E-4 3.9 E-1 (oral) 1.2 E+0 Lead and lead compounds (inhalation) D A 1.2 E-5 4.2 E-2 (oral) D A 8.5 E-3 Lindane D A 3.1 E-4 1.1 E+0 Methyl tert-butyl ether (MTBE) G/I A 2.6 E-7 1.8 E-3 3-Methylcholanthrene BaP 6.3 E-3 2.2 E+1 Footnotes # [100 PCM fibers/m 3 ] -1 ; see Appendix D * can be calculated using PEF factors contained in the benzo[a]pyrene TAC document A see Appendix A BaP see benzo[a]pyrene TAC document; calculated from unit risk/cancer potency factors for BaP using PEF factors D Listed by ARB as “Particulate Matter from Diesel-Fueled Engines”; Scientific Review Panel unit risk “reasonable estimate” = 3.0 E-4 (µg/m 3 ) -1 . Range of unit risks in TAC document was 1.3 E-4 – 2.4 E-3 (µg/m 3 ) -1 . P See chemical summary for risk categorization Exposure Routes D = diet; DW = drinking water; G = gavage; I = inhalation; O = other oral route Study Type A = animal; H = human Document Source bold type = TAC document Animal Unit Risk, Slope Factors C = obtained from Cal/EPA or CDHS risk assessment; I = obtained from US EPA IRIS listing 592
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Air Toxics Hot Spots Program Risk A
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Prepared by: John D. Budroe, Ph.D.
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This document is one of five docume
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TABLE OF CONTENTS PREFACE i INTRODU
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N-Nitrosodimethylamine 401 N-Nitros
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Hot Spots Unit Risk and Cancer Pote
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Additional ATES and PETS documents
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data. If several data sets (dose an
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US EPA Calculation of Carcinogenic
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exposure to a concentration of 1 µ
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incidences for each of the dose lev
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computes the surface area of a sphe
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Comparison of Hot Spots Cancer Unit
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Gold, L., de Veciana, M., Backman,
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Animal Studies Rats Woutersen et al
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ased on sufficient evidence of carc
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ACETAMIDE CAS No: 60-35-5 I. PHYSIC
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Methodology Expedited Proposition 6
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cancer mortality. However, US EPA (
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Table 2. Lung adenoma incidence in
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Table 3 (continued). Acrylamide-ind
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Robinson M, Bull RJ, Knutsen GL, Sh
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Also, a trend was observed correlat
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eported. Cause-specific expected de
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Bio/Dynamics Inc. conducted a study
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examination. Interim sacrifices wer
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Table 8. Tumor incidence in male an
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Gaffey WR and Strauss ME. 1981. A m
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(technical grade; 98% pure) by gava
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International Agency for Research o
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still alive in the low-dose control
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ANILINE CAS No: 62-53-3 I. PHYSICAL
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fibrosarcomas, stromal sarcomas, ca
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ARSENIC (INORGANIC) CAS No: 7440-38
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elationship between arsenic exposur
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al. (1988) did not induce lung tumo
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A risk assessment was also conducte
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Chen C, Chuang Y, You S, Lin T and
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Schrauzer G, White D, McGinness J,
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Table 1: Summary of epidemiologic s
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had at least one animal demonstrati
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mesothelioma, recommended lifetime
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National Institute for Occupational
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BENZENE CAS No: 71-43-2 I. PHYSICAL
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Animal Studies Available experiment
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Table 3: Summary of NTP bioassay re
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Table 4: Summary of benzene low-dos
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Maltoni C, Conti B and Cotti G. 198
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a benign tumor of the kidney. No ba
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al. (1968) found no tumors in lifet
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following relationship, where C(t 1
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Miakawa M. and Yoshida O. 1975. Pro
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human population and that BPDE-DNA
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demonstrated the tumor initiating a
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Table 4: Bronchoalveolar tumors fro
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Table 5: IARC groupings of PAHs, mi
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Table 6 (continued): IARC Group 3 P
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Potency Equivalency Factors (PEF) f
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This was rounded to a PEF of 0.1. 1
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experiment (Takayama et al., 1985)
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Deutsch-Wenzel RP, Brune H, Grimmer
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Krewski D, Thorslund T and Withey J
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U.S. Environmental Protection Agenc
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Sorahan et al. (1983) studied cance
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Lijinsky W. 1986. Chronic bioassay
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the drinking water (Schroeder and M
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Table II. Effective dose, upper-bou
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BIS(2-CHLOROETHYL)ETHER CAS No: 111
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IV. DERIVATION OF CANCER POTENCY Ba
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BIS(CHLOROMETHYL)ETHER CAS No: 542-
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Table 1. Bis(chloromethyl)ether-ind
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Drew RT, Laskin S, Kuschner M and N
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ates for the 1968 U.S. male populat
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Table 1: Incidence of primary tumor
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National Institute of Occupational
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was less than 0.05 when controlling
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up period. The final cohort include
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If the cadmium-exposed workers incl
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on personnel records (20%); (3) eva
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were exposed to a continuous (23.5
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procedure (NLIN), the parameters we
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International Agency for Research o
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Two reports were published on cance
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Mendel rats, respectively), and sub
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Eschenbrenner A and Miller E. 1946.
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III. CARCINOGENIC EFFECTS Human Stu
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cancers, were less than expected. T
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and no cases of cancer (although cl
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There was a statistically significa
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NTP (1982a) also conducted an carci
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Several pathologists have independe
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hepatocellular adenoma/carcinoma tu
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carcinogenic potency may decline in
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Cochrane W, Singh J and Miles W. 19
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North Atlantic Treaty Organization,
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CHLORINATED PARAFFINS (average chai
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ased on dose-response data for beni
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chloroform in drinking water with k
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Overall, the present epidemiologica
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female dogs received toothpaste bas
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Calculated q 1 * values from the ab
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Hogan MD, Chi Py, Hoel DG and Mitch
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Table 1. Study design summary for N
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V. REFERENCES California Environmen
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toluidine. Followup of this subcoho
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feeding studies on by NCI (1979) us
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CHROMIUM (HEXAVALENT) CAS No: 18540
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expected rate may be inflated becau
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Oral Borneff et al. (1968) exposed
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CREOSOTE (COAL TAR-DERIVED) CAS No:
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from an inhalation exposure study (
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Table 1. Study design summary for N
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Table 1. Experimental design for ca
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Hazardous Substance Data Bank (HSDB
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Table 1: Tumor induction in Fischer
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Table 1. Experimental design of 2,4
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Additional analysis of these data b
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Jackson RJ, Greene CJ, Thomas JT, M
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Table 1. Tumor incidence in rats ex
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Girard R, Tolot F, Martin P and Bou
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exposed more than 16 years before t
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interpretation of dose extrapolatio
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1, 1-DICHLOROETHANE CAS No: 75-34-3
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Table 1b. Study design for carcinog
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National Cancer Institute (NCI) 197
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mice, hepatocellular carcinoma inci
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V. REFERENCES California Department
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DAB/day by gavage for the life of t
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2,4-DINITROTOLUENE CAS No: 121-14-2
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Ellis et al.(1979) (also reported b
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Final Statement of Reasons for OAL,
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to the small sample size and short
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In an inhalation study, Torkelson e
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V. REFERENCES American Conference o
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EPICHLOROHYDRIN CAS No: 106-89-8 I.
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espiratory tumors were noted in the
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Table 4. Epichlorohydrin-induced fo
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Konishi Y, Kawabata A, Denda A, Ike
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exposed to arsenicals for 20 months
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espectively (all statistically sign
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ETHYLENE DICHLORIDE CAS No: 107-06-
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Several factors have been suggested
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myelogenous leukemias (4 and 8 year
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statistically significant. CDHS not
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combined with the incidence in the
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incidence of primary brain tumors.
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Table 6 (continued): Organ/Sex Mali
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An Upper 95% Confidence Limit (UCL)
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ETHYLENE THIOUREA (ETU) CAS No: 96-
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male and female rats. Tumor inciden
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FORMALDEHYDE CAS No: 50-00-0 I. PHY
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presented an extension of a previou
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Methodology In developing a spectru
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Casanova M, Morgan KT, Steinhagen W
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Tobe M, Kaneko T, Uchida Y, Kamata
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Table 1. Hexachlorobenzene-induced
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50 pups (F 1 ) of each sex were ran
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Ertürk E, Lambrecht RW, Peters HA,
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Table 1. Liver hepatoma incidence i
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1988). An airborne unit risk factor
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HYDRAZINE CAS No: 302-01-2 I. PHYSI
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Methodology Inhalation A linearized
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LEAD AND LEAD COMPOUNDS (INORGANIC)
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and other occupational carcinogens
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y inhalation is similar for rats an
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Goyer RA. 1992. Nephrotoxicity and
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LINDANE (g-Hexachlorocyclohexane) C
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Using these relationships, a human
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METHYL TERT-BUTYL ETHER (MTBE) CAS
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Tumor incidences according to the r
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kidney changes indicative of chroni
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Interspecies scaling for oral doses
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Table 4 (continued): Dose Response
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Experimental Pathology Laboratories
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Animal Studies Male and female HaM/
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Gold L, Sawyer C, Magaw R, Backman
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Using the statistical tests (one-ta
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Table 1: Methylene chloride-induced
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Significant treatment-related incre
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National Toxicology Program (NTP) 1
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noted; however, the study duration
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Crump KS, Howe RB, Van Landingham C
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Table 1. Michler’s ketone-induced
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NICKEL AND NICKEL COMPOUNDS CAS No:
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the high exposure group was 14.0. A
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male and 121 female rats, was expos
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2.1 - 2.6 × 10 -4 (µg/m 3 ) -1 .
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The increased incidence of bladder
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A linearized multistage procedure w
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N-NITROSO-N-METHYLETHYLAMINE CAS No
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propylamine in drinking water at 0.
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N-NITROSODIETHYLAMINE CAS No: 55-18
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Table 2. Treatment groups, concentr
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California Department of Health Ser
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animals and the second generation t
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ationale for selection of the OEHHA
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A unit risk value based upon air co
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N-NITROSODIPHENYLAMINE CAS No: 86-3
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Methodology Dosage estimates of NDP
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Crump KS, Howe RB. 1984. The multis
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Table 1. P-Nitrosodiphenylamine-ind
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N-NITROSOMORPHOLINE CAS No: 59-89-2
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N-NITROSOPIPERIDINE CAS No: 100-75-
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Table 3. N-Nitrosopiperidine-induce
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Crump KS, Howe RB, Van Landingham C
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testicular tumors were noted in the
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PARTICULATE MATTER FROM DIESEL-FUEL
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etired railroad workers who had had
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employment (χ 2 test for trend: p
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elevated smoking-adjusted risk esti
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Table 1 (continued): Reference Miln
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Table 1 (continued): Reference Damb
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Table 1 (continued): Reference Burn
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Table 1 (continued): Reference Raff
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Table 1 (continued): Epidemiologica
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Table 1 (continued): Epidemiologica
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Table 1 (continued): Reference Wegm
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Animal Studies Section 6.1 (Animal
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The variability, or heterogeneity,
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estimate for those studies for whic
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Figure 1: Estimates of Relative Ris
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q 1 * = Excess relative risk × CA
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Table 3: Number of Workers in the E
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u nexposed workers at zero concentr
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for each µg/m 3 of diesel exhaust
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Table 4: Values from Unit Risk for
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their findings that a reasonable es
Page 479 and 480:
Garshick E, Schenker M, Woskie S an
Page 481 and 482:
Lewis T, Green, FH MW, Burg J and L
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Rothman K. 1986. Modern epidemiolog
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PENTACHLOROPHENOL CAS No: 87-86-5 I
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The default lifespan for mice is 10
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documented. An excess risk from ski
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B6C3F 1 mice and F344/N rats were e
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This model, rather than a time depe
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POLYCHLORINATED BIPHENYLS (PCBs) CA
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several benign adenomatous lesions
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Ito et al. (1973) exposed groups of
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could not be characterized by chlor
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exposure (all pathways and mixtures
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National Toxicology Program 1993. T
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Table 1. Potassium bromate-induced
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1,3-PROPANE SULTONE CAS No: 1120-71
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Page 513 and 514:
PROPYLENE OXIDE CAS No: 75-56-9 I.
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oxide. In the NTP carcinogenicity s
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1,1,2,2-TETRACHLOROETHANE CAS No: 7
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assumed a body weight of 70 kg and
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total); an untreated control group
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TOLUENE DIISOCYANATE CAS No: 26471-
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Animal Studies The National Toxicol
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Mortillaro PT and Schiavon M. 1982.
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male or female rats. Increases in h
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TRICHLOROETHYLENE CAS No: 79-01-6 I
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A mortality analysis of a cohort of
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elative to that of the controls whi
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applied or metabolized. The range o
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Katz RM and Jowett D. 1981. Female
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10,000 ppm 2,4,6-trichlorophenol in
Page 543 and 544:
Page 545 and 546:
Bionetics Research Laboratories. 19
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control; females: 6/10 exposed, 0/1
Page 549 and 550: over controls (p < 0.04). Other tum
Page 551 and 552: was increased (100/314 exposed vs.
Page 553 and 554: Table 3. Cancer potency estimates f
Page 555 and 556: Crouch E. 1983. Uncertainties in in
Page 557 and 558: VINYL CHLORIDE CAS No: 75-01-4 I. P
Page 559 and 560: Table 1 (continued): A Summary of E
Page 561 and 562: al., 1983). Histopathology of all o
Page 563 and 564: Table 3: Tumor incidences in 100 pp
Page 565 and 566: experiment, animals were exposed to
Page 567 and 568: Experiment BT1 Most previous risk a
Page 569 and 570: No statistical analyses of mortalit
Page 571 and 572: Table 11 gives unit risk estimates
Page 573 and 574: Bertazzi PA, Villa A, Foa V, Saia B
Page 575 and 576: Nicholson WJ, Hammond EC, Seidman H
Page 577 and 578: immunotoxicity, reproductive toxici
Page 579 and 580: scheme. TEFs for two major noncance
Page 581 and 582: NATO/CCMS (1988a) Pilot Study on In
Page 583 and 584: Table 2 Toxicity Equivalency Factor
Page 585 and 586: Table 4 A Comparison of CTEF- and I
Page 587 and 588: Office of Environmental Health Haza
Page 589 and 590: Group 4: The agent is probably not
Page 591 and 592: TECHNICAL SUPPORT DOCUMENT FOR DESC
Page 593 and 594: US EPA IRIS Inhalation Unit Risk an
Page 595 and 596: TECHNICAL SUPPORT DOCUMENT FOR DESC
Page 597 and 598: as appropriate, and revise IRIS fil
Page 599: Chemical Exposure Route Study Type
Page 603 and 604: Chemical Exposure Route Study Type
Page 605 and 606: Methyl tert-butyl ether p. 5: Added
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