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Table 1.
Hexachlorobenzene-induced tumor incidence in male and female Syrian golden
hamsters (Cabral et al., 1977)
Dietary HCB
concentration
(mg/kg diet)
Calculated daily
intake
(mg/kg-day)
Tumor type
Tumor incidence
males females
0 0 hepatomas 0/40 0/39
50 4 14/30 14/30
100 8 26/30 17/30
200 16 49/57 51/60
0 0 hemangioendotheliomas 0/40 0/39
50 4 1/30 0/30
100 8 6/30 2/30
200 16 20/57 7/60
0 0 thyroid adenomas 0/40 0/39
50 4 0/30 2/30
100 8 1/30 1/30
200 16 8/57 3/60
Outbred Swiss mice were fed diets containing 0, 50, 100, or 200 mg/kg hexachlorobenzene for 101-
120 weeks; all surviving animals were killed at 120 weeks (Cabral et al., 1979). Initial group sizes
were 50 animals/sex for the control and 200 mg/kg diet groups, and 30/sex for the 50, 100 and 300
mg/kg diet groups. A dose-response related increase in the incidence of liver tumors (unspecified
histological type) was noted in both male and female animals. An increased incidence of liver tumors
was also found in a group of 30 males and 30 females fed diet containing 300 mg/kg diet HCB for 15
weeks followed by observation until 120 weeks. Tumor incidence data is listed in Table 2.
Table 2.
Hexachlorobenzene-induced liver tumors in male and female Swiss mice (Cabral et al.,
1979)
Dose group
Tumor incidence
(mg/kg diet)
males
females
0 0/47 0/49
50 0/30 0/30
100 3/29 3/30
200 7/44 14/41
300 (15 weeks exposure) 1/16 1/26
320