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POTASSIUM BROMATE
CAS No: 7758-01-2
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 167.01
Boiling point
not available
Melting point 434 °C
Vapor pressure
not available
Air concentration conversion 1 ppm = 6.8 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 1.4 E-4 (µg/m 3 ) -1
Slope Factor: 4.9 E-1 (mg/kg-day) -1
[Male rat kidney tumor data (Kurokawa et al., 1983), contained in Gold et al. (1987)
database, expedited Proposition 65 methodology (Cal/EPA, 1992), with cross-route
extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of potassium bromate in humans are known to exist.
Animal Studies
Male and female Wistar rats (90/sex/group) (Fisher et al., 1979) and “Theiller’s Original” strain mice
(60/sex/group) (Ginocchio et al., 1979) were fed diets consisting of 79% bread crumbs made from
untreated flour, or flour containing 50 mg/kg or 75 mg/kg potassium bromate. Mice and rats were fed
treated diet for 80 and 104 weeks, respectively. No significant increase in tumor induction was
reported; however, IARC (1986) noted that bromates are substantially degraded during bread baking.
Male and female Fischer 344 (F344) rats were exposed to 0, 250 or 500 mg/l potassium bromate in
drinking water for 100 weeks (Kurokawa et al., 1983). Group sizes were 52-53/sex/group. Total
doses were 9.6 and 21.3 mg/kg body weight for low and high dose males, respectively, and 9.6 and
19.6 mg/kg body weight for low and high dose females, respectively. Significant increases in the
incidences of renal andenomas and adenocarcinomas were noted in both males and females; significant
increases were also noted in the incidence of peritoneal mesotheliomas in males, and of thyroid tumors
in females. Tumor incidence data is listed in Table 1.
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