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ALLYL CHLORIDE
CAS No: 107-05-1
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB, 1994)
Molecular weight 76.5
Boiling point
44.96°C
Freezing point
-134.5°C
Vapor pressure 295.5 mm Hg at 20°C
Air concentration conversion 1 ppm = 3.13 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 6.0 E-6 (µg/m 3 ) -1
Slope Factor: 2.1 E-2 (mg/kg-day) -1
[Linearized multistage procedure (GLOBAL82) (US EPA, 1986) fitted to NCI (1977) female
mouse forestomach tumor data, body weight scaling, adopted by RCHAS/OEHHA (1994),
cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
A retrospective cohort mortality study of 1,064 male workers potentially exposed to epichlorohydrin
and allyl chloride was conducted by Olsen et al. (1994). Study subjects had a minimum of 1 month
work experience between 1957-1986 in the production or use of epichlorohydrin and allyl chloride and
1 year total employment duration at Dow Chemical’s Texas Operations (Freeport, TX). Job exposure
categorization was used to quantify individual exposure based on an evaluation of work practices,
production processes and available environmental monitoring data. Vital status follow-up occured
through 1989; 66 total deaths were recorded. Standardized mortality ratios (SMR) for all malignant
neoplasms or lung cancer were not significantly increased when compared to external (U.S.) or internal
(Texas Operations) populations. The authors noted that the study results are limited by the cohort’s
size, duration of follow-up, relatively few number of observed and expected deaths, and the level of
potential epichlorohydrin and allyl chloride exposure.
Animal Studies
Several studies exist on the potential carcinogenicity of allyl chloride in animals; these studies have been
reviewed by IARC (1985) and U.S. EPA (1986, 1991).
Male and female B6C3F 1 mice and Osborne-Mendel rats (50/group) were exposed to allyl chloride
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