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2-AMINOANTHRAQUINONE
CAS No: 117-79-3
I. PHYSICAL AND CHEMICAL PROPERTIES (From HSDB (1994) except where
noted)
Molecular weight 223.24
Boiling point sublimes (IARC, 1982)
Melting point 302 °C
Vapor pressure
not available
Air concentration conversion 1 ppm = 9.131 mg/m 3
II.
HEALTH ASSESSMENT VALUES
Unit Risk Factor: 9.4 E-6 (µg/m 3 ) -1
Slope Factor: 3.3 E-2 (mg/kg-day) -1
[Male rat liver tumor data (NCI, 1978), contained in Gold et al. database (1984), expedited
Proposition 65 methodology (Cal/EPA, 1992), cross-route extrapolation.]
III.
CARCINOGENIC EFFECTS
Human Studies
No studies on the potential carcinogenic effects of 2-aminoanthraquinone (2-AA) on humans are known
to exist.
Animal Studies
Results from the National Cancer Institute (NCI) (1978) feeding study in male and female B6C3F 1
mice and Fischer 344 rats are tabulated in Gold et al. (1984). 2-Aminoanthraquinone (technical grade,
unspecified impurities) was administered in feed to groups of 50 male and 50 female animals of each
species. Matched control groups were included for each mouse dose group (50 animals/sex/species).
Control groups of 50 male and 25 female rats were also included; these animals were observed for
107-109 weeks. Diet fed to mice contained 5000 or 10000 mg/kg 2-AA; diet fed to female rats
contained 2000 mg/kg 2-AA. Diet fed to male rats contained 10000 or 20000 mg/kg 2-AA for the
first 10 weeks; this was reduced to 2500 or 5000 mg/kg for the remaining 68 weeks. For rats, NCI
reported the time-weighted average dietary concentrations to be 0.69% and 0.35% for high and low
dose males, and 0.2% for treated females over a 78-week period. An additional observation period of
28-32 weeks was included after treatment ended. High and low dose mice of both sexes were
administered time-weighted average dietary concentrations of 1.0% (over 80 weeks) and 0.5% (over
78 weeks) respectively, and were observed for an additional 15-16 weeks after treatment ended.
At study termination, 82, 78, 94 and 86% of male mice and 78, 76, 88 and 76% of female mice were
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