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Table 6.
Tumor incidence in male Sprague-Dawley rats exposed to acrylonitrile in drinking water
(Quast et al., 1980a)
Tumor type
Tumor incidence
Acrylonitrile dose level (ppm)
0 35 100 300
brain and/or spinal cord 1 1/80 12/47 22/48 30/48
nonglandular forestomach 2 0/80 3/46 23/48 39/47
tongue 2 1/75 2/7 4/9 5/40
Zymbal gland carcinomas 3/80 4/47 3/48 15/48
1. Benign and/or malignant
2. Squamous cell papillomas and/or carcinomas
Table 7.
Tumor incidence in female Sprague-Dawley rats exposed to acrylonitrile in drinking
water (Quast et al., 1980a)
Tumor type
Tumor incidence
Acrylonitrile dose level (ppm)
0 35 100 300
brain and/or spinal cord 1 0/80 17/48 22/48 24/48
mammary gland 1 57/80 42/48 42/48 35/48
nonglandular forestomach 2 1/80 1/47 12/48 30/48
small intestine 3 0/80 1/7 4/11 4/48
tongue 2 0/78 1/5 2/3 12/45
Zymbal gland carcinomas 4 1/80 5/48 8/48 18/48
1. Benign and/or malignant
2. Squamous cell papillomas and/or carcinomas
3. Mucinous cystadenocarcinomas
4. Adenomas and carcinomas
Male and female Sprague-Dawley rats (Spartan substrain; 100 animals/sex/exposure group) were
exposed to acrylonitrile by inhalation in a study conducted by Dow Chemical Company for the
Chemical Manufacturers Association (Quast et al., 1980b). Study animals were exposed to 0, 20 or
80 ppm of acrylonitrile for 6 hours/day, 5 days/week for 2 years. Statistically significant increases in
tumor incidence were noted for the following tumor types: brain and spinal cord glial cell tumors (males
and females), mammary gland adenocarcinomas (females), small intestine tumors (benign and malignant)
(males), tongue squamous cell papillomas and carcinomas (males) and Zymbal gland tumors (males and
females). All tumor incidence increases were noted at the highest concentration tested, 80 ppm, except
for brain and spinal cord glial cell tumors in females, which were also noted in the 20 ppm group. Tumor
incidence data are listed in Table 8.
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