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Table 3.
N-Nitrosopiperidine-induced tumor induction in male and female Syrian golden
hamsters (Ketkar et al., 1983)
Dose group
(% N-nitrosopiperidine)
Average dose 1
(mg/kg-day)
Tumor type Tumor incidence 2
male
respiratory tract
0 0 0/50
0.006 7.2 5/30
0.025 30 10/30
0.05 60 15/30
female
respiratory tract
0 0 0/50
0.006 8.18 4/30
0.025 34.1 6/30
0.05 68.2 10/30
male
liver tumors
0 0 0/50
0.006 7.2 1/30
0.025 30 2/30
0.05 60 10/30
female
liver tumors
0 0 0/50
0.006 8.18 1/30
0.025 34.1 2/30
0.05 68.2 4/30
male
digestive tract
0 0 0/50
0.006 7.2 0/30
0.025 30 4/30
0.05 60 13/30
female
digestive tract
0 0 0/50
0.006 8.18 4/30
0.025 34.1 5/30
0.05 68.2 7/30
1. Doses as reported by Gold et al. (1984).
2. Tumor incidences as reported by Gold et al. (1984).
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