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1260A AASLD ABSTRACTS HEPATOLOGY, October, 2015 DM-HCC individuals than DM-non-HCC individuals (OR 3.44, p = 0.0002). The influence of PNPLA3 and JAZF1 was independent of age, sex, and body mass index after multivariable logistic regression analysis. There were no differences in the allele frequencies of PNPLA3 and JAZF1 between the HCV- HCC and HCV-non-HCC groups. Conclusions: The PNPLA3 rs738409 was determined to be associated with HCC development in non-viral hepatitis patients with T2DM. Additionally, the JAZF1 rs864745 was identified as a risk factor for HCC among T2DM patients with the GG genotype at PNPLA3 rs738409. Disclosures: The following authors have nothing to disclose: Misuzu Ueyama, Masaaki Korenaga, Nao Nishida, Keiko Korenaga, Erina Kumagai, Masaya Sugiyama, Yoshihiko Aoki, Masatoshi Imamura, Kazumoto Murata, Naohiko Masaki, Takumi Kawaguchi, Takuji Torimura, Hideyuki Hyogo, Hiroshi Aikata, Kiyoaki Ito, Yoshio Sumida, Tatsuya Kanto, Sumio Watanabe, Masashi Mizokami 2159 Older Age, Increasing Body Mass Index, and Concurrent Diabetes Mellitus Increases Risk of Advanced Fibrosis Among Nonalcoholic Fatty Liver Disease Patients Maria Aguilar 2 , Edward W. Holt 3 , Taft Bhuket 1 , Benny Liu 1 , Zobair M. Younossi 4,5 , Aijaz Ahmed 6 , Robert J. Wong 1 ; 1 Gastroenterology and Hepatology, Alameda Health System - Highland Hospital, Oakland, CA; 2 Medicine, Alameda Health System - Highland Hospital, Oakland, CA; 3 Transplantation - Division of Hepatology, California Pacific Medical Center, San Francisco, CA; 4 Medicine - Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA; 5 Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA; 6 Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA Background:Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease (CLD) in the U.S. and will become the leading etiology of hepatocellular carcinoma and liver transplantation. However, the true prevalence of NAFLD and NAFLD with advanced fibrosis (NAFLD-AF) is not well understood. Aim:To determine the current prevalence and predictors of NAFLD and NAFLD-AF among U.S. adults. Methods:Using the most recent 2011-2012 U.S. National Health and Nutrition Examination Survey, we defined NAFLD as presence of both abnormal alanine aminotransferase (ALT>20 U/L in women, ALT>30 U/L in men) and metabolic syndrome after excluding other CLD etiologies (eg. hepatitis C, hepatitis B, alcohol). NAFLD-AF was defined as NAFLD fibrosis score > 0.676. Prevalence estimates were stratified by sex, ethnicity, and age. Multivariate logistic regression models evaluated predictors of NAFLD and NAFLD-AF. Results:Overall NAFLD prevalence was 21.1%, representing 49.2 million persons. NAFLD prevalence was higher in females compared to males (31.4% vs. 14.0%, p60: 48.2% vs. age
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 1261A regression analysis of biomarkers indicated that HA, CK18 and TIMP1 were independent predictor of advanced fibrosis (odds ratio [OR] HA=1.057, CK18=1.002, TIMP1=0.99, 95% CI, p
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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