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792A AASLD ABSTRACTS HEPATOLOGY, October, 2015 related to coexisting factors such as depression, PTSD and disease beliefs. The effect of successful treatment on hopelessness in this cohort is being evaluated. Disclosures: Zobair M. Younossi - Advisory Committees or Review Panels: Salix, Janssen, Vertex; Consulting: Gilead, Enterome, Coneatus Michael P. Curry - Advisory Committees or Review Panels: Bristol Meyers Squib, Abbvie; Grant/Research Support: Gilead Sciences, Mass Biologics, Merck, Salix, Conatus; Stock Shareholder: Achilion The following authors have nothing to disclose: Sophie K. Afdhal, Michael Penn 1178 Sofosbuvir is well tolerated and effective in chronic hepatitis C patients with advanced renal disease and/or on hemodialysis Geoffrey Kitzman 1 , Eric Davis 1 , Jesus Monico 2 , Evelyn Arendale 1 , Brian B. Borg 1 ; 1 Digestive Disease, University of Mississippi Medical Center, Jackson, MS; 2 Pathology, University of Mississippi Medical Center, Jackson, MS Background: Sofosbuvir (Sof) is a nucleotide analog inhibitor of HCV NS5B polymerase. It is used in combination therapies with ribavirin or other DAAs. The safety and efficacy of sofosbuvir in patients with advanced renal disease (GFR
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 793A could potentially select F0–2 treatment-naïve G4 patients suitable to shorten SMV+PR therapy to 12 weeks. Disclosures: Tarik Asselah - Consulting: Jannsen, AbbVie, Achillion, BMS, Gilead, Merck, Roche; Speaking and Teaching: Jannsen, AbbVie, Achillion, BMS, Gilead, Merck, Roche Christophe Moreno - Consulting: Abbvie, Janssen, Gilead, BMS; Grant/Research Support: Janssen, Gilead, Roche, Astellas Christoph Sarrazin - Advisory Committees or Review Panels: Bristol-Myers Squibb, Janssen, Merck/MSD, Gilead, Roche, Abbvie, Janssen, Merck/MSD; Consulting: Merck/MSD, Merck/MSD; Grant/Research Support: Abbott, Roche, Merck/MSD, Gilead, Janssen, Abbott, Roche, Merck/MSD, Qiagen; Speaking and Teaching: Gilead, Novartis, Abbott, Roche, Merck/MSD, Janssen, Siemens, Falk, Abbvie, Bristol-Myers Squibb, Achillion, Abbott, Roche, Merck/MSD, Janssen Michael Gschwantler - Advisory Committees or Review Panels: Janssen, BMS, Gilead, AbbVie; Speaking and Teaching: Janssen, BMS, Gilead, AbbVie Graham R. Foster - Advisory Committees or Review Panels: GlaxoSmithKline, Novartis, Boehringer Ingelheim, Tibotec, Chughai, Gilead, Janssen, Idenix, GlaxoSmithKline, Novartis, Roche, Tibotec, Chughai, Gilead, Merck, Janssen, Idenix, BMS; Board Membership: Boehringer Ingelheim; Grant/Research Support: Chughai, Roche, Chughai; Speaking and Teaching: Roche, Gilead, Tibotec, Merck, BMS, Boehringer Ingelheim, Gilead, Janssen Peter Buggisch - Advisory Committees or Review Panels: Janssen, AbbVie, BMS; Speaking and Teaching: Roche, MSD, Gilead, Merz Pharma Faisal M. Sanai - Advisory Committees or Review Panels: Merck Sharpe Dohme, Bristol Myers Squibb, Janssen Pharmaceuticals, Gilead Sciences; Grant/ Research Support: Roche Pharmaceuticals, Bristol Myers Squibb; Speaking and Teaching: Roche Pharmaceuticals, Janssen Pharmaceuticals, Gilead Sciences, Bayer Schering Robert Ryan - Employment: Janssen Pharmaceuticals; Stock Shareholder: Janssen Pharmaceutical Oliver Lenz - Employment: Janssen; Stock Shareholder: Janssen (J&J) Gino Van Dooren - Stock Shareholder: Johnson and Johnson Isabelle Londjon-Domanec - Employment: Janssen Catherine Nalpas - Employment: Janssen pharmaceuticals Michael Schlag - Employment: Janssen Cilag Pharma; Stock Shareholder: Johnson & Johnson Maria Buti - Advisory Committees or Review Panels: Gilead, Janssen, MSD; Grant/Research Support: Gilead, Janssen; Speaking and Teaching: Gilead, Janssen, BMS The following authors have nothing to disclose: Antonio Craxi 1180 Rapid drop in serum glucose and hypoglycemia in chronic hepatitis C patients with diabetes during oral HCV therapy Laura M. Benítez-Gutiérrez 1 , Vincent Soriano 2 , Isabella Esposito 1 , Pablo Barreiro 2 , Ana Maria Duca 1 , Silvia Requena 1 , Isolina Baños 1 , Ana Treviño 1 , Valentin Cuervas-Mons 1 , Carmen de Mendoza 1 ; 1 Internal Medicine, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; 2 Infectious Disease Unit,, La Paz University Hospital & IdiPAZ, Madrid, Spain Introduction: Chronic HCV infection is associated with metabolism abnormalities, including insulin resistance. Up to 15-25% of chronic hepatitis C patients will develop diabetes lifelong. New DAA allow HCV suppression within a very short-time frame. Little is known on the metabolic effects seen in chronic hepatitis C patients on DAA. Methods: All chronic hepatitis C patients that received sofosbuvir (SOF)-based regimens during at least 4 weeks at two reference hepatitis clinics in Madrid were retrospectively examined. Results: A total of 61 chronic hepatitis C patients begun SOF-based regimens and had weeks 0 and 4 controls. Regimens were as follows: SOF+simeprevir (16), SOF+daclatasvir (13), SOF+ledipasvir (27) and SOF+ribavirin (5). At 4 weeks 63% had undetectable viremia and the rest had
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Page 536 and 537: 742A AASLD ABSTRACTS HEPATOLOGY, Oc
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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