studies

908A AASLD ABSTRACTS HEPATOLOGY, October, 2015
1431
Risk of cirrhosis in first degree relatives of patients with
NAFLD cirrhosis: A prospective study
Rohit Loomba 1 , Jeffrey Y. Cui 2 , Ricki Bettencourt 3 , Nicholas
Schork 4 , Chi-Hua Chen 5 , Mahdi Al Ikhwan 2 , Archana Bhatt 2 ,
Lisa M. Richards 2 , Claude B. Sirlin 5 , David A. Brenner 2 ; 1 Division
of Gastroenterology and Epidemiology, University of California
at San Diego, La Jolla, CA; 2 Gastroenterology, UCSD School of
Medicine, La Jolla, CA; 3 Family and Preventive Medicine, UCSD
School of Medicine, La Jolla, CA; 4 J Craig Venter Institute, La Jolla,
CA; 5 Radiology, UCSD School of Medicine, La Jolla, CA
Background: The risk of cirrhosis in the first-degree relative of
patients (pts) with NAFLD-cirrhosis is unknown & needs to be
determined. This determination would help develop guidelines
for cirrhosis screening in first-degree relatives of patients with
NAFLD-cirrhosis. Aim: To determine the risk of NAFLD-cirrhosis
in first-degree relatives of pts with known NAFLD cirrhosis.
Methods: This is a cross-sectional analysis of two prospectively
recruited familial cohorts: the familial NAFLD-cirrhosis cohort &
the control-families cohort. The familial cirrhosis cohort included
pts with known NAFLD-cirrhosis (probands) recruited from the
UCSD NAFLD Clinic & their first-degree relatives. The controls
were derived from a community-dwelling cohort of normal
twin/sib-sib/parent-offspring pair with one random participant
as a control & the respective pair as the first-degree relative
recruited from the general population of Southern California.
Probands had documented evidence of NAFLD (based upon
AASLD Guidelines) & either biopsy-proven or imaging-proven
cirrhosis. The first-degree relatives of pts with NAFLD-cirrhosis
& controls underwent a research visit & advanced MRI +MRE
to detect advanced fibrosis (MRE liver stiffness >3.63 kPa has
an AUROC 0f 0.93). Multivariable-adjusted logistic regression
(odds ratio [OR]) was done to examine the risk of cirrhosis in
first-degree relatives of pts with cirrhosis. Results: This study
included 19 probands (mean age 62.5 yrs & BMI 32.3 kg/
m 2 ) with NAFLD-cirrhosis, & 36 first-degree relatives (mean
age 47.4 yrs & BMI 30.9 kg/m 2 ) of probands. The controls
(mean age 40.9 yrs & BMI 25.5 kg/m 2 ) included 61 pairs
(total n=122) of either twin/sib-sib/parent-offspring pair;
with 61 without any evidence of NAFLD or cirrhosis, and 61
first-degree relatives of these randomly ascertained unaffected
first-degree relative pairs. The prevalence of NAFLD-cirrhosis in
the first degree relatives of pts with NAFLD-cirrhosis was significantly
higher than the controls (13.9 % vs. 1.6%, p