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912A AASLD ABSTRACTS HEPATOLOGY, October, 2015 1439 Comparison of 16 blood and/or elastometric fibrosis tests in 5 causes of chronic liver diseases: too much? Towards a simplification Jerome Boursier 1,2 , Alexandra Ducancelle 3,2 , Vincent Leroy 4 , Julien Vergniol 5 , Nathalie Sturm 6 , Brigitte Le Bail 7 , Jean-Pierre H. Zarski 4 , Victor de Ledinghen 5 ; 1 Hepato-Gastroenterology Departement, University Hospital, Angers, France; 2 HIFIH Laboratory EA3859, University, Angers, France; 3 Virology Department, University Hospital, Angers, France; 4 Hepato-Gastroenterology Department, University Hospital, Grenoble, France; 5 Hepatology Department, University Hospital, Bordeaux, France; 6 Pathology Department, University Hospital, Grenoble, France; 7 Pathology Department, University Hospital, Bordeaux, France Introduction: Most non-invasive fibrosis tests were developed in chronic hepatitis C (CHC), but are frequently used in other causes. A lot of tests are available. Therefore, we compared the accuracy of several usual tests between main etiologies to try to determine whether a test could be the most performant in several etiologies. Methods: Populations included 1660 patients: 698 with CHC, 178 with hepatitis B (CHB), 444 with HIV/CHC, 225 with NAFLD, and 115 with alcoholic liver disease (ALD). 16 tests (13 blood tests, 1 elastometry by VCTE -Fibroscan- and 2 combining blood markers and elastometry) were evaluated. Reference was Metavir fibrosis (F) stage by liver biopsy. Results: Accuracy was sensitive to biopsy length. Obuchowski indices, reflecting accuracy for all F stages, were by decreasing order, CHC: Elasto-FibroMeter VCTE2G/3G : 0.812, FibroMeter VIRUS2G : 0.797, FibroMeter VIRUS3G : 0.785, CirrhoMeter VIRUS2G : 0.771, Fibrotest: 0.762, CirrhoMeter VIRUS3G : 0.756, Fibroscan: 0.754, Hepascore: 0.752, FibroMeter ALD : 0.750, APRI: 0.742, FIB4: 0.741. CHB: Obuchowski indices were roughly the same as in CHC. HIV/CHC: Obuchowski indices were moderately decreased compared to CHC except for Fibrotest (p=0.03). NAFLD: 7 tests had a substantial accuracy loss compared to CHC, especially Fibrotest (p=0.006), while 5 tests had a substantial gain especially FibroMeter ALD (p=0.039) and Zeng score (p=0.030). ALD: 2 tests had a dramatic accuracy loss compared to CHC: APRI (p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 913A 1441 Comparing the liver stiffness by transient elastography in cirrhosis patients with PBC and HBV to predict the risk of esophageal variceal bleeding Ying Huang 1 , Haiyun Zhang 1 , Li Xiao 1 , Liqing Zhu 1 , Qingjing Zhu 2 , Xiaohua Hou 1 , Ling Yang 1 ; 1 Division of Gastroenterology,Department of Internal Medicine, Huazhong University of Science&Technology, Wuhan, China; 2 Wuhan Medical Treatment Center, Wuhan, China Background&Aim: Staging hepatic fibrosis is critical for the evaluation and deternination of prognosis in chronic liver diseases. Variceal bleeding is the servere complications of liver cirrhosis. Endosocopy as the only means to evaluate the varices and risk of bleeding is not an easy examination to be accepted by patients with expensive price and poor tolerance. Transient elastography (TE) is useful as non-invasive diagnositic method for predicting liver stiffness and portal hypertension. Our aim was to analyze the diagnostic accuracy of liver stiffness measurement(LSM) and the esophageal variceal grading and the risk of esophageal variceal bleeding in different etiological cirrhosis patients with HBV infection or primary billiary cirrhosis by transient elastography. Patients and Methods: Endoscopy and transient elastography were performed in 24 primary biliary cirrhosis patients and 66 hepatitis B related cirrhosis. The relationships of the liver stiffness between esophageal variceal degree and the risk of esophageal variceal bleeding, as well as the hematological and biochemical laboratory parameters were analyzed. Results: The grade of esophageal varices is highly correlated with the stiffness of the liver(P
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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