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392A AASLD ABSTRACTS HEPATOLOGY, October, 2015 (r=0.68). exRNA aligned read counts were lower in cancer than in normal bile samples. Read counts between cancer and normal bile exRNA samples had a wide range of correlation (r: 0.64 to 0.95). A set of 14 mature (sense and antisense) miRNA were differentially expressed > 3SD fold change in expression (based on reads per million) in bile from CCA compared with normal bile. Other differentially expressed exRNA identified included tRNA and piRNA. Summary and Conclusions: Biliary exRNA sequencing provides a novel strategy for biomarker discovery. exRNA isolation protocols have a major impact on yield and quality of exRNA for downstream gene expression studies. Differentially expressed candidate exRNA biomarkers have been identified that may be useful for the diagnosis of CCA. Disclosures: The following authors have nothing to disclose: Irene K. Yan, Waseem David, Swathi Mohankumar, Sarah Nix, Hiroaki Haga, Yan W. Asmann, Tushar Patel 359 Risk Differences of Hepatocellular Carcinoma (HCC) Among Patients with Chronic Hepatitis C (CHC) of Different Viral Genotypes: a Historical Cohort Study in the United States Mingjuan Jin 2,1 , Changqing Zhao 1,7 , Joseph K. Hoang 1 , Nghia H. Nguyen 1,3 , An K. Le 1 , Christine Y. Chang 1 , Richard H. Le 1 , Alina Kutsenko 4 , Lee Ann Yasukawa 5 , Jian Q. Zhang 6 , Susan C. Weber 5 , Mindie H. Nguyen 1 ; 1 Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA; 2 Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou, China; 3 Department of Medicine, University of California, San Diego, San Diego, CA; 4 Department of Medicine, Stanford University Medical Center, Palo Alto, CA; 5 Center for Clinical Informatics, Stanford University School of Medicine, Palo Alto, CA; 6 Chinese Hospital, San Francisco, CA; 7 Department of Cirrhosis, Institute of Liver Disease, Shuguang Hospital, Shanghai University of T.C.M., Shanghai, China Purpose: Whether there exists differences in the risk for HCC among patients with CHC of different genotypes is still controversial, which were explored in the present study in a historical cohort from 2 ethnically diverse US centers. Methods: The subject inclusion was as follows: CHC patients aged 20 years or older, presented at study centers between 1/1/1999 and 12/31/2013, followed up for at least 1 year, having HCV genotype information, and no HCC at baseline. The HCC cumulative incidence and incidence density were calculated. Cox proportional hazards models were used to testify the associations of HCV genotypes with HCC. Results: A total of 1990 eligible CHC patients were included, among whom 1174 (59.0%) were female and 1594 (80.1%) were ≤ 60 years old with mean age of 53.20±9.63 years. The ethnicity distribution was 7.9% for Asian, 40.6% for White, 18.3% for Hispanc and Black, and 33.2% for others and unknown. The frequencies of genotypes 1a/untyped, 1b, 2, 3, and others (genotype 4 and 6) were 51.4%, 18.6%, 13.0%, 13.1%, and 3.9%, respectively. Overall, the 1-year, 3-year and 5-year HCC cumulative incidence were 448.53, 1341.88, and 2354.31 per 10,000 persons, respectively, with the incidence density of 297.37 per 10, 000 person-years in this cohort. Compared to patients with the most prevalent genotype 1a/untyped, the age-, gender- and ethnicity-adjusted hazard ratios (95%CIs) were 0.88 (0.64-1.22), 0.58 (0.37-0.93), 1.42 (0.99-2.04), and 1.89 (1.14-3.14) for those with genotype 1b, 2, 3, and 4 and 6, respectively. Conclusions: The results suggest that HCV genotype 4 and 6 are associated with the highest risk of HCC, and genotype 2 has the lowest risk, and there were no significant differences between genotype 1b and 1a/untyped . Preventive measures such as antiviral therapy and HCC surveillance efforts should especially target the higher risk groups. Disclosures: Mindie H. Nguyen - Advisory Committees or Review Panels: Bristol-Myers Squibb, Bayer AG, Gilead, Novartis, Onyx; Consulting: Gilead Sciences, Inc.; Grant/Research Support: Gilead Sciences, Inc., Bristol-Myers Squibb, Novartis Pharmaceuticals, Roche Pharma AG, Idenix, Hologic, ISIS The following authors have nothing to disclose: Mingjuan Jin, Changqing Zhao, Joseph K. Hoang, Nghia H. Nguyen, An K. Le, Christine Y. Chang, Richard H. Le, Alina Kutsenko, Lee Ann Yasukawa, Jian Q. Zhang, Susan C. Weber 360 Surveillance for Hepatocellular Carcinoma (HCC) Using Ultrasonography Alone is Associated with Improved Survival: Results of Inverse Probability of Treatment Weighting (IPTW)-Based Survival Analysis Piyanat Chattieng 2 , Jonggi Choi 1 , Nopavut Geratikornsupuk 2 , Kessarin Thanapirom 2 , Sombat Treeprasertsuk 2 , Piyawat Komolmit 2 , Roongruedee Chaiteerakij 2,1 ; 1 Mayo Clinic, Rochester, MN; 2 Medicine, Chulalongkorn University, Bangkok, Thailand Background/Aim: The current American Association for the Study of Liver Disease guideline recommend HCC surveillance program using ultrasound modality alone. The impact of the surveillance program on survival remains unclear due to unavoidable bias and confounders in observational studies. We aimed to determine the effect of HCC surveillance on survival using an IPTW analysis controlling for inherent bias and confounders existing in observational studies. Methods: We conducted a retrospective cohort study of 446 patients with cirrhosis and/ or chronic hepatitis B infection who were diagnosed with HCC between 2007 and 2013 in a major referral center in Bangkok, Thailand. Surveillance was defined as having repeated abdominal ultrasonography within 1 year prior to HCC diagnosis. Survivals of patients with and without surveillance were estimated using the Kaplan-Meier method with lead-time bias adjustment and compared using the log-rank test. Hazard ratio (HR) and 95% confidence interval (CI) of surveillance was computed using conventional Cox and weighted Cox proportional hazards analysis with IPTW adjustment. Results: Of the 446 HCC patients, 79% were male with a mean age of 58.1 years. Hepatitis B (54%), hepatitis C (20%), alcohol (11%) and non-alcoholic fatty liver disease (9%) were the most common underlying chronic liver diseases. A hundred and three (23%) were diagnosed with HCC through surveillance. The surveillance group had a higher proportion of patients diagnosed with the Barcelona-Clinic Liver Cancer (BCLC) stage A (82% vs. 34%, P
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 393A P=0.005. The estimated effect of surveillance remained similar using IPTW-adjusted Cox analysis, with HR (95% CI) of 0.57 (0.43-0.76), P
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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