studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 215A
15
Effect of HCV treatment outcome on hospitalization rate:
Chronic Hepatitis Cohort Study (CHeCS)
Eyasu H. Teshale 1 , Jian Xing 1 , Anne C. Moorman 1 , Scott D. Holmberg
1 , Stuart C. Gordon 2 , Loralee B. Rupp 2 , Mei Lu 2 , Philip R.
Spradling 1 , Joseph A. Boscarino 3 , Connie M. Trinacty 4 , Mark A.
Schmidt 5 , Fujie Xu 1 ; 1 CDC, Atlanta, GA; 2 Henry Ford Health System,
Detroit, MI; 3 Geisinger Health System, Danville, PA; 4 Kaiser
Permanente Hawaii, Honolulu, HI; 5 Kaiser Permanente Northwest,
Portland, OR
Background: Chronic hepatitis C virus (HCV) infection is associated
with high all-cause hospitalization rates. Hospitalization
rates increase with increasing severity of liver disease. Successful
treatment of chronic HCV infection results in reduced
morbidity and mortality. The objective of this study is to determine
the association between HCV treatment outcome and
hospitalization rate. Methods: We used data from HCV-infected
patients seen in four large U.S. healthcare systems from
2006-2012. We included persons who received HCV treatment
during this time and who had follow up before and after
completion of treatment. Treatment outcome was grouped as
sustained virologic response (SVR) or treatment failure (TF). We
determined hospitalization rates [per 100 person years (PY)]
before and after treatment (SVR or TF) and excluded hospitalizations
during treatment. Results: Between 2006 and 2012,
1409 persons received HCV therapy; 680 (48.3%) achieved
SVR and 729 (51.7%) had TF. The overall before treatment
hospitalization rate was 13.2/100 PY; before treatment hospitalization
rates for those who achieved SVR and those with
TF were 10.6/100 PY and 16.0/100 PY, respectively. The
after treatment hospitalization rate decreased to 5.6/100 PY
for those who achieved SVR (p