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782A AASLD ABSTRACTS HEPATOLOGY, October, 2015 breakthrough. Only 2 cases experienced viral relapse and 93% of patients achieved SVR 4w. The response rate was tend to be higher in patients treated with pitavastain and EPA and significantly lower for patients with resistance-associated polymorphism (80%, p= 0.002) or treated cases with simeprevir (20%, p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 783A ropoietin. Among pts receiving TPV+pegIFN/RBV, 12 (10%) were transfused and 1 received erythropoietin due to anemia. Conclusions: In MALACHITE-I and MALACHITE-II, 3D+/-RBV had more favorable AE profiles than TPV+pegIFN/RBV. With 3D+/-RBV, anemia was less frequent and less severe, and never required transfusion or use of erythropoietin. RBV was better tolerated in the context of newer DAAs than of TPV and pegIFN. Adverse events and hemoglobin decreases in MALACHITE-I and MALACHITE-II. *P1755μg.h/L after the first dose is predictive of sustained virological response (SVR) in HCV-patients treated with peginterferon/RBV*. The aim of this study was to test the clinical benefit of RBV early dose adjustment based on this threshold (Bayesian estimation) in under-exposed naïve genotype 1-infected patients. Methods: multicenter, randomized, controlled trial with two parallel groups; SC-group: standard of care in 2010- 2011, i.e. peginterferon-α2a 180μg/week and weight-based RBV 1000-1200mg/day during 48 weeks; AD-group: personalized increase of RBV dose if D0AUC 0-4H
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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