studies

826A AASLD ABSTRACTS HEPATOLOGY, October, 2015
1246
IgG4 status in explanted livers may affect the outcome
of Primary sclerosing cholangitis (PSC) after liver transplantation
Mansour G. Alghanem 1 , Bandar Al-Judaibi 2 , Paul Marotta 2 , Subrata
Chakrabari 3 , Chaturika Herath 3 ; 1 mansour alghanem, university
of western ontario, London, ON, Canada; 2 Hepatology,
Western university, London, ON, Canada; 3 Western university,
London, ON, Canada
BACKGROUND: The outcome of Primary Sclerosing Cholangitis
(PSC) after liver transplantation can be affected by recurrent
PSC (rPSC) and subsequent graft failure. IgG4 related sclerosing
disease is a recent entity that has a similar morphological
appearance to PSC, making the distinction difficult. However,
IgG4 related sclerosing cholangitis has an excellent prognosis
since, it is steroid sensitive, but the impact of IgG4 on rPSC
after liver transplant is still unknown. AIM: To determine the
association between IgG4 immunochemical staining in liver
explants and recurrence of primary sclerosing cholangitis postliver
transpantation METHODS: All adult patients who underwent
liver transplantation for PSC,from 1990 to 2014, were
identified. Clinical inforamtion and immunochemical staining
were obtained among the patietns with PSC recurrence postliver
transplantation. IgG4 immunochemical staining was perforemed
on the porta-hepatis region. Immunochemical staining
is considered to be positive if the score was >5 cells/HPF.
RESULTS: A total of eighty patients fulfilled the criteria for the
study. IgG4 staining was positive in 21/80 (26%) subjects
(>5cells/HPF). Median time for follow-up in IgG4 positive
group was 99.6 months compared to 152.6 months in the
IgG4 negative There were more episodes of rPSC in IgG4
positive group (P