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1290A AASLD ABSTRACTS HEPATOLOGY, October, 2015 2220 Transient Elastography is Feasible with High Success Rate for Evaluation of Non-Alcoholic Fatty Liver Disease (NAFLD) in a Multicenter Setting Raj Vuppalanchi 1 , Mohammad S. Siddiqui 2 , Erin K. Hallinan 3 , Manal F. Abdelmalek 4 , Brent A. Neuschwander-Tetri 5 , Rohit Loomba 6 , Kris V. Kowdley 7 , Norah Terrault 8 , Arthur J. McCullough 9 , James Tonascia 3 , Elizabeth M. Brunt 10 , David E. Kleiner 11 , Edward Doo 12 , Naga P. Chalasani 1 , Arun J. Sanyal 2 ; 1 Indiana University, Indianapolis, IN; 2 Virginia Commonwealth, Richmond, VA; 3 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 4 Duke, Durham, NC; 5 St.Louis University, St.Louis, MO; 6 University of California at San Diego, San Diego, CA; 7 Swedish Medical Center, Seattle, WA; 8 University of California at San Francisco, San Francisco, CA; 9 Cleveland Clinic, Cleveland, OH; 10 Washington University, St.Louis, MO; 11 NCI, Bethesda, MD; 12 NIH, Bethesda, MD Background: Vibration-controlled transient elastography using FibroScan to obtain the liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) is a promising non-invasive tool for assessment of hepatic fibrosis and steatosis respectively. However, prior <strong>studies</strong> using older versions of FibroScan reported high failure rates in nonalcoholic fatty liver disease (NAFLD). Aim: The aim of the current study was to examine the feasibility and success of the FibroScan 502 Touch in patients with NAFLD who were participating the NAFLD Database Study conducted by the NASH Clinical Research Network (NASH CRN). Methods: A total of 511 NAFLD patients across eight clinical centers were eligible and provided informed consent. The FibroScan 502 Touch was used in all patients with either the medium (M+) or large (XL+) probes. Both LSM and CAP were measured after an overnight fast using a standardized protocol. The scanning was performed twice (FS1 and FS2) during the same study visit. “Failure” was defined as the inability to obtain a valid exam whereas “unreliable” was defined as those exams with 30%. Results: The cohort included 65% women with a mean (± SD) age of 56 (± 12) years, BMI 33.6 (± 6.8) kg/m 2 and waist circumference 107 (± 14) cm. Based on the recommendations from the automatic probe selection tool, XL+ probe was required for the study in 57% of patients. Five patients (1.0%) refused the procedure after providing informed consent and five patients (1.0%) had a skin-to-capsule distance greater than 3.5 cm and the exam could not be completed. Among remaining 501 patients, the results were unreliable in 8 (1.6%). Using logistic regression analysis, only female gender [OR: 0.29, 95%CI: 0.10, 0.83, p=0.02) and waist circumference [OR: 1.04 per cm, 95%CI: 1.01, 1.08, p=0.004) were associated with a failed or unreliable exam. There was excellent agreement between FS1 and FS2 for LSM (r=0.96, 95% CI: 0.95, 0.97) and CAPs (r=0.81, 95% CI: 0.77, 0.84). In a subset of patients who had a liver biopsy within 12 months of the FibroScan (n=74), log-linear regression analysis showed statistically significant relationships between the geometric mean (GM) LSM and advanced (stage 3 or 4) vs. no or less advanced fibrosis [GM ratio: 2.04 (95% CI: 1.60, 2.60), p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 1291A Disclosures: The following authors have nothing to disclose: Claudia P. Oliveira, José Tadeu Stefano, Roberto M. Ribeiro, Sebastião M. Duarte, Livia Rodrigues, Priscila B. Campos, Fernando G. Costa, Daniel F. Mazo, Flair J. Carrilho, Ester C. Sabino 2222 Outcome of bariatric surgery, in highly selected morbid obese with compensated cirrhosis Guillaume Lassailly, Robert Caiazzo, Charlotte Vanveuren, gnemmi vivianne, Alexandre Louvet, Emmanuelle Leteurtre, Florent Artru, Sebastien Dharancy, Valerie Canva, Francois Pattou, Philippe Mathurin; CHRU lille, Lille, France Introduction: Morbid obesity contributes to liver function impairment in cirrhotic patients and especially in NASH. Weight loss strategies could improve liver function, but bariatric surgery is not considered due to an increased risk of mortality after surgery. However its benefit and feasibility in highly selected patients is still unclear. The aim of this study was to describe the outcome of highly selected cirrhotic patients after bariatric surgery. Methods: Among the 2024 morbid obese patients of the Lille Bariatric prospective cohort (1994-2015), 28 compensated cirrhotic patients underwent bariatric surgery. When cirrhosis was identified before surgery, each case was discussed to validate the procedure. Only Child-Pugh A5 patients without portal hypertension (without varice and hepatic vein gradient
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208A AASLD ABSTRACTS HEPATOLOGY, Oc
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1340A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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