studies

1282A AASLD ABSTRACTS HEPATOLOGY, October, 2015
MTs had HCC (7.0% Vs 3.1%, p=0.004) at presentation.
Conclusions: A significant number (52.7%) of NASH related
cirrhotics had FH for T2DM. Importantly, FH of T2DM constitutes
a high risk group for early and severe cirrhosis. Community
based research to further substantiate this hypothesis and
health education strategies to disseminate relevant awareness,
is a prime requisite.
Disclosures:
The following authors have nothing to disclose: Ajeet S. Bhadoria, Chandan K.
Kedarisetty, Ankit Bhardwaj, Guresh Kumar, Tanmay S. Vyas, Jaya Benjamin,
Varsha Shasthry, Manoj Kumar, Shiv K. Sarin
2204
Non-alcoholic Fatty Liver Disease (NAFLD) Is Associated
with Impairment of Health Related Quality of Life
(HRQoL): Data from US Population
Munkhzul Otgonsuren 2 , Rebecca Cable 2 , Sean C. Felix 2 , Patrick
W. Austin 2 , Yun Fang 2 , Zobair M. Younossi 2,1 ; 1 Center For Liver
Disease, Department of Medicine, Inova Fairfax Hospital, Falls
Church, VA; 2 Betty and Guy Beatty Center for Integrated Research,
Inova Health System, Falls Church, VA
Background and Aim: NAFLD is an important cause of chronic
liver disease (CLD). Our aim was to assess the impact of NAFLD
on patients’ HRQoL in the US adult population. Methods:
National Health and Nutrition Examination Survey (NHANES
2001-2011) was used to identify adults with NAFLD [Fatty Liver
Index (FLI)>60 in the absence of other causes of liver disease,
chronic diseases and excessive alcohol use]. Subjects without
any of these conditions were considered as healthy controls.
Patients with HCV RNA(+) were considered as HCV-controls.
All patients completed HRQoL-4 questionnaire: (1) Component
1 (C1) rate health status as poor, fair, good, very good, or
excellent; (2) C2: thinking about your physical health, which
includes physical illness and injury, for how many days during
the past 30 days was your physical health not good; (3) C3:
thinking about your mental health, which includes stress,
depression, and problems with emotions, for how many days
during the past 30 days was your mental health not good; and
(4) C4: about how many days did poor physical/mental health
keep him/her from doing your usual activities, such as selfcare,
work, or recreation. Linear regression models adjusted
for age, gender, race, and BMI was used to assess associations.
Results: 9,661 NHANES participants (3,333 NAFLD,
346 HCV+ and 5,982 controls). The proportion of subjects
rating their health as “fair” or “poor” was higher in NAFLD
(20%) than healthy controls (10%). However, 30% of HCV
reported poor to fair health (all p