studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 833A
Disclosures:
The following authors have nothing to disclose: Michael Cheung, She-Yan Wong,
Arun Mathew, Dina Halegoua-De Marzio
1262
Downstaging or Bridging Therapy of Hepatocellular
Cancer Does Not Increase Incidence of Biliary Complications
after Liver Transplantation
Meera Ramanathan 2 , Mark Pedersen 2 , Myunghan Choi 3 , Anil B.
Seetharam 1 ; 1 Banner Transplant and Advanced Liver Disease Center,
University of Arizona College of Medicine-Phoenix, Phoenix,
AZ; 2 Internal Medicine, University of Arizona College of Medicine-Phoenix,
Phoenix, AZ; 3 Arizona State University College of
Nursing and Health Innovation, Phoenix, AZ
Background: Donor and vascular risk factors predisposing to
bile duct ischemia are causes of biliary complications after liver
transplant (LT). Manipulation of the hepatic artery prior to LT as
often occurs in the management of hepatocellular cancer (HCC)
may represent a novel risk factor for non anastomotic biliary
complications. Aim: Evaluate effect of pre-LT hepatic artery
based locoregional therapy on incidence of non anastomotic
biliary complications after LT. Methods: Retrospective cohort
study of consecutive LT recipients between 2009 and 2013.
Incidence of non anastomotic biliary complications (stricture
or leak) tabulated by review of radiologic or endoscopic cholangiogram.
Univariate regression evaluated donor, recipient,
surgical, and locoregional treatment variables associated with
increased risk of biliary complication: cytomegalovirus (CMV)
donor status, organ source (brain or cardiac death), donor
age, native model for end stage liver disease (MELD) and body
mass index (BMI) at LT, etiology of cirrhosis (viral vs. non-viral),
warm ischemic time, cold ischemic time, need for take back surgery
to control bleed in the 1 st month post LT, number of lesions
at the time of HCC diagnosis, modality of arterial locoregional
treatment (chemo vs radio-embolization) and number of treatment
sessions. Variables of interest (p