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494A AASLD ABSTRACTS HEPATOLOGY, October, 2015 The following authors have nothing to disclose: Luca Fabris, Stefano Okolicsanyi, Matteo Rota, Paolo Cortesi, Luca S Belli, Stefano Fagiuoli, Luciana Scalone, Giancarlo Cesana, Mario Strazzabosco 572 Knowledge about hepatitis B transmission risks among health professionals in Tanzania Jose Debes 1 , Johnstone Kayandabila 2 , Hope Pogemiller 1 ; 1 University of MInnesota, Minneapolis, MN; 2 Arusha Lutheran Medical Centre, Arusha, United Republic of Tanzania Introduction: It is well known that hospital workers are at increased risk for contracting hepatitis B virus (HBV). This risk it is increased in settings of high HBV seroprevalence, such as sub-Saharan Africa. Despite this, it is unclear whether healthcare providers in developing countries are aware of the transmission risks and adhere to universal precaution strategies. In this study we aimed to evaluate the knowledge and understanding of HBV among health-care workers in hospitals in Tanzania. Methods: We provided a HBV survey to staff in 2 hospitals in northern Tanzania. The survey consisted of nine multiple-choice questions that inquired about understanding of HBV serostatus, vaccination and risks of transmission of HBV. The survey was written in English and Swahili (the local language) and distributed among medical and non-medical staff (laboratory technicians, students, etc). Multivariate analyses were performed using Fishers exact test and Chi-square. Results: We received voluntary participation from 114 subjects in our survey. The mean age of the participants was 33 y/o, 67% were females, and 61% responded to the survey in English. Ninety one percent of subjects had no knowledge of their HBV surface antigen status, and 89% indicated they never received a vaccine for HBV, with lack of knowledge about the vaccine being the most common reason (34%). Seventy percent of participants new about HBV complications and 60% responded correctly inquires about transmission routes. There was a significant difference in knowledge of HBV serostatus and vaccination between participants with a medical background (consultants, interns, etc) and others, p=0.01 and p-0.001 respectively. However, only 33% of consultants knew about their HBV serostatus or were vaccinated for it. There was no significant difference between knowing HBV transmission route or in-hospital risk and whether the survey was answered in English or local language, or hospital position of the responder. Conclusions: Our study shows a surprisingly low knowledge of HBV serostauts and vaccination status among hospital workers in Tanzania. Studies are needed in other parts of sub-Saharan Africa to further understand this gap in knowledge, and HBV awareness programs should be promoted. Disclosures: The following authors have nothing to disclose: Jose Debes, Johnstone Kayandabila, Hope Pogemiller 573 Hepatitis C Virus Sustained Virologic Response Rates among Patients Treated in Primary Care Settings in New York State Colleen Flanigan, Jason Pendergast; New York State Department of Health, Albany, NY Background Hepatitis C virus (HCV) treatment has been rapidly changing over the last few years. With the arrival of direct acting anti-viral therapies, HCV treatment is now highly effective. As a result of these more effective treatments, the demand for HCV treatment is increasing, adding strain to an already limited number of specialists available to treat HCV. The newer treatments are less complex, more tolerable and treatment durations can be as short as eight weeks, thus, allowing for primary care providers (PCPs) to treat HCV. To expand access to HCV care and treatment in New York State (NYS), the NYS Department of Health provides funding to 13 primary care sites to integrate HCV care and treatment. These primary care sites include: community health centers, hospital-based clinics, a methadone maintenance treatment program and a residential drug treatment program. At each of these settings, a PCP and a multidisciplinary team manages and treats persons infected with HCV. Each PCP is an experienced HCV provider with the knowledge and skills to safely and effectively manage and treat HCV. Each PCP has an agreement with a liver specialist for consultation. The purpose of this study was to evaluate HCV treatment sustained virologic response (SVR) rates among patients receiving HCV treatment in a primary care setting. Methods This analysis looks at HCV SVR rates among HCV monoinfected and HIV/HCV coinfected patients enrolled at 13 primary care sites across NYS. All primary care sites report client level data using the AIDS Institute Reporting System (AIRS). AIRS is a comprehensive client and service/encounter reporting application. AIRS also collects HCV treatment type and treatment outcome (SVR). Results From October 1, 2010 through April 30, 2015, 2,447 HCV infected patients were served by the 13 primary care sites. Of these patients, 816 (33.3%) initiated HCV treatment and of these patients 743 (91.1%) had final treatment outcomes available for analysis. The overall SVR rate among these patients was 61.5%; 70.1% among HCV monoinfected and 50.8% among HIV/HCV coinfected patients. SVR rates ranged from 49.3% among those treated with the combination pegylated interferon and ribavirin to as high as 96.6% among those treated with ledipasvir-sofosbuvir. Conclusions These findings illustrate that HCV treatment SVR rates are just as good in primary care settings as they are in specialty settings. Therefore, integrating HCV treatment into primary care can help increase capacity for HCV treatment and allow more people to be cured of HCV. Disclosures: The following authors have nothing to disclose: Colleen Flanigan, Jason Pendergast 574 External Validity of Trials in Non-Alcoholic Fatty Liver Disease: Systematic Review of Randomised Controlled Trials and Non-Randomised studies Richard Parker 1 , James Hodson 2 , Ian A. Rowe 1 ; 1 Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; 2 University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom Introduction Trials with good external validity allow clinicians and patients to have confidence in new treatments. Individuals in clinical trials are often highly selected, in part to remove confounding factors, but this can introduce bias and limit the external validity of a trial. In this study, we surveyed observational studies and randomised controlled trials (RCT) to gauge the external validity of trials in non-alcoholic fatty liver disease (NAFLD). Methods Structured literature searches were undertaken for observational studies (ObS) and RCT in NAFLD. Data were extracted from included studies. Participant characteristics were compared between observational studies and RCT, and between subsets of observational studies describing with biopsy-proven non-alcoholic steatohepatitis (NASH) or advanced fibrosis (>F2). For age and BMI, weighted means were calculated and compared with t-tests, for prevalence of Diabetes mellitus (DM) and gender, Chi-squared was used for comparisons.
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 495A Results 112 studies were included: 47 RCT and 65 ObS. Sixteen observational studies described characteristics of patients with NASH and 31 described characteristics of patients with advanced fibrosis. RCT participants differed from individuals in ObS with regard to age, BMI, prevalence of DM, and gender (p
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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