studies

636A AASLD ABSTRACTS HEPATOLOGY, October, 2015
860
Living donor liver transplantation for patients with HCC
exceeding Milan criteria: results of pilot study.
Josep M. Llovet 1,2 , Mihai-Calin Pavel 3 , Jordi Rimola 1 , Maria
Alba Diaz 4 , Jordi Colmenero 3,5 , Constantino Fondevila 3 , Josep
Fuster 1,3 , Pere Gines 3,5 , Jordi Bruix 1,5 , Juan Carlos García-Valdecasas
3 ; 1 Liver Unit, BCLC, IDIBAPS, CIBEREHD, Universitat de Barcelona,
Barcelona, Spain; 2 Institució Catalana de Recerca i Estudis
Avançats, Barcelona, Spain; 3 Liver Transplant Unit, Digestive and
Metabolic Diseases Institute, Hospital Clinic, University of Barcelona,
Barcelona, Spain; 4 Pathology Department, Hospital Clinic,
University of Barcelona, Barcelona, Spain; 5 Liver Unit, Digestive
and Metabolic Diseases Institute, Hospital Clinic, University of Barcelona,
Barcelona, Spain
Introduction: Liver transplantation is the standard of care for
patients with hepatocellular carcinoma (HCC) within Milan criteria
not suitable for resection. Nonetheless, during the last
20 years it became apparent that a subset of patients beyond
Milan criteria might obtain acceptable survival outcomes. In
parallel, living donor liver transplantation has emerged as a
feasible alternative to overcome the paucity of donors. Methods:
In 2002, we proposed for LDLT in Child A-B patients with
HCC a set of criteria that substantially expanded the conventional
indications of transplantation (1 tumor up to 7cm, 5
tumors of < 3cm, 3 tumors < 5cm, or downstaging to Milan
lasting 6 mo after loco-regional therapies) (Bruix& Llovet, Hepatology
2002). Results: We herein present a prospective cohort
of 22 patients with HCC fulfilling these criteria that were treated
with LDLT between 2002 and 2014. Median age was 57 yrs,
20 men, HCV related 14, Child-Pugh A:16, B:6, AFP