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956A AASLD ABSTRACTS HEPATOLOGY, October, 2015 1529 Elevated galectin-3 in cirrhotic heart increases TNFα and inhibits cardiac contractility in rats Hongqun Liu, Samuel S. Lee; university of calgary, Calgary, AB, Canada Background: Galectin-3 plays a key pathogenic role in heart failure. However, the role of galectin-3 in cirrhotic cardiomyopathy is unclear. The present study aimed to investigate the effects of galectin-3 on cardiomyopathy. Methods: Two sets of rats were used in this study, one to study structural changes and another for a functional study. There were 4 groups (n=6 in each group) in each set: bile duct ligation (BDL); BDL + galectin-3 inhibitor (N-acetyllactosamine, LacNAc, 5 mg/kg); sham operation and sham + LacNAc. The rats were sacrificed 4 weeks after surgery. Cardiac mRNA and protein contents were evaluated by RT-PCR and Western blots (Galectin-3, PKCα, fibronectin, collagen I and III). Heart and serum TNFα was measured by ELISA. Isolated cardiomyocyte contractility was measured by an IonOptix cell-shortening video system. Results: the galectin-3, fibronectin and collagen I/ III ratio were significantly increased in cirrhotic hearts. TNFα was significantly increased in BDL rats in both serum and heart compared with sham controls (744 ± 84 pg/ml vs 566 ± 61 pg/ml in serum, p< 0.01 and 310 ± 32 pg/mg protein vs 189 ± 21 pg/ mg protein in heart, p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 957A Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triglyceride hydrolysis in adipose tissue, muscle, and liver. In a murine model of cancer cachexia, global deletion of ATGL prevented tumor-induced weight loss by inhibiting both adipose tissue and skeletal muscle wasting. Whether tissue-specific ATGL inactivation can ameliorate chronic-liver disease associated cachexia is unknown. Our aim was to determine the role of adipose tissue ATGL on cachexia development in a murine model of biliary injury (bile duct ligation). Methods: Adipose-tissue specific ATGL-knockout (AAKO, N = 10) and wild type C57/BL6 (N = 10) male mice 10-15 weeks old were treated with bile duct ligation (BDL) or sham laparotomy. Calorie intake and body weight were measured weekly. Body composition was determined weekly using Echo-MRI, and 36-hour respiratory exchange ratio (RER) and activity were measured in an Oxymax Comprehensive Laboratory Animal Monitoring System (CLAMS). Animals were sacrificed 4 weeks after surgery. Results: At baseline, AAKO mice exhibited increased adipose tissue mass compared to WT mice. BDL-treated WT and AAKO mice developed moderate fibrosis by Sirius Red staining. There were no differences in caloric intake between genotypes and treatment groups. BDL significantly reduced fat mass and lean mass (% total body weight) in AAKO mice only (p
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1006A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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