studies

416A AASLD ABSTRACTS HEPATOLOGY, October, 2015
Disclosures:
The following authors have nothing to disclose: Yutaka Midorikawa, Tadatoshi
Takayama
408
Elevated Serum Wisteria floribunda agglutinin-positive
human Mac-2 binding protein predict all-cause mortality
in hepatitis C patients with hepatocellular carcinoma
Shigemune Bekki, Kazumi Yamasaki, Yuuki Sonoda, Yuki Kugiyama,
Satoru Hashimoto, Akira Saeki, Shinya Nagaoka, Seigo
Abiru, Atsumasa Komori, Hiroshi Yatsuhashi; National Organization
Hospital Nagasaki Medical Center, Omura, Japan
Background & Aims: Serum glycosylated Wisteria floribunda
agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP)
has been recently reported as a noninvasive and useful surrogate
marker for the degree of liver fibrosis and for the risk of
hepatocellular carcinoma (HCC). We investigated the utility
of WFA(+)-M2BP to predict all-cause mortality in the patients
with hepatitis C virus (HCV)-related hepatocellular carcinoma
(HCC). Patients & Methods: A total of 466 HCV-related HCC
patients who had been admitted to our hospital from 1999
to 2013 were enrolled. We evaluated association between
mortality and clinicolaboratory variables, included age, sex,
asparate and alanine aminotransferase levels (AST and ALT),
bilirubin, albumin, prothrombin activity, platelet count, Child-
Pugh grade, alpha-fetoprotein (AFP), des-γ-carboxy prothrombin
(DCP), TNM stage, and WFA(+)-M2BP. The average
observation period was 3.7 years. The association between
WFA(+)-M2BP and mortality was evaluated using the Cox proportional
hazards regression analysis. Results: The baseline
characteristics of the 466 patients were 295 (63.2%) male with
a median age of 70.0 years. The median value of WFA(+)-
M2BP was 4.6 (range, 0.2-18.36) cutoff index (COI). Serum
WFA(+)-M2BP levels significantly correlated with bilirubin
(r=0.26, p