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358A AASLD ABSTRACTS HEPATOLOGY, October, 2015 is similar to previous reports. Guidelines recommend a paracentesis to evaluate for SBP in patients admitted with ascites, but do not address evaluation for SBP in outpatients. In outpatients, the need for routine ascitic fluid analysis in asymptomatic patients is an area of discussion based on a reported low prevalence of SBP. This study suggests that similar to inpatients, all asymptomatic outpatients undergoing paracentesis should routinely have ascitic fluid analyzed to assess for SBP. Disclosures: Maria Sjogren - Speaking and Teaching: Gilead, Bristol Myers The following authors have nothing to disclose: Dustin Albert, Manish B. Singla, Frank Cheng, Dawn Torres 286 Is Midodrine, Octreotide, and Albumin still worthwhile therapy for Hepatorenal Syndrome Type 1 (HRS1)? Katherine Hahn 1 , Amen Javaid 1 , Pooja Singhal 2 , Franca B. Barton 3 , James H. Lewis 2 ; 1 Internal Medicine, Georgetown University Hospital, Washington, DC; 2 Georgetown University, Washington, DC; 3 The EMMES Corporation, Rockville, MD Introduction: HRS1 is a fatal complication of advanced cirrhosis, with mortality rates as high as 80% within 2 weeks of diagnosis. Current treatment options in the United States include vasoconstrictors (e.g.: midodrine [M], octreotide [O], and vasopressin), often combined with albumin [A], transjugular intrahepatic portosystemic shunt (TIPS), renal replacement therapy (RRT), and liver transplantation (LT). This retrospective study analyzes the outcomes of 137 HRS1 patients treated with MOA as primary therapy or as a bridge to LT. Methods: A retrospective cohort study evaluated HRS1 patients treated with MOA at Georgetown University Hospital over a 6 year period (Jan 2009 – Dec 2014). The demographics, underlying liver disease, creatinine levels, MELD scores, RRT requirements, and LT rates of these MOA patients were collected. The primary end point was survival to hospital discharge. Secondary outcomes included survival after RRT and survival with/without LT. The effects of patient characteristics on survival were tested with a Cox proportional hazards model. The relationship between LT and survival was analyzed using logistic regression. Results: From 2009-2014, a total of 238 patients were treated with MOA. Of these, 101 patients did not meet the diagnostic criteria for HRS1 and were excluded. Of the remaining 137 patients, 70 (51%) had SBP, 73 (52.9%) received RRT, but only 34 (24.8%) met criteria to undergo LT. The overall survival to discharge was 33%. Among those who survived, 57.1% had received LT and 42.8% had not. Factors showing a significant effect on survival were LT (p=0.015), MELD score
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 359A 288 Acute kidney injury in cirrhotic patients undergoing contrast-enhanced computed tomography Roberto Filomia 1 , Sergio Maimone 1 , Carlo Saitta 1 , Luca Visconti 5 , Simona Caloggero 4 , Antonio Bottari 4 , Alessia Pitrone 4 , Angela Alibrandi 3 , Irene Cacciola 1 , Gaia Caccamo 1 , Domenica Vadalà 1 , Carmine G. Gambino 1 , Maria Stella Franzè 1 , Giovanni Raimondo 1 , Giovanni Squadrito 1,2 ; 1 Clinical and Molecular Hepatology, University Messina, Messina, Italy; 2 Human Pathology, University of Messina, Messina, Italy; 3 Department of Economical, Business and Environmental Sciences and Quantitative Methods, Univeristy of Messina, Messina, Italy; 4 Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 5 Internal Medicine, Unit Of Nephrology, Messina, Italy Introduction: Contrast-induced acute kidney injury (CI-AKI) following intravenous contrast medium administration is one of the most common causes of hospital-acquired acute kidney damage. Aim: To investigate the incidence and possible predisposing factors of CI-AKI in cirrhotic patients undergoing contrast-enhanced computed tomography (CECT). Patients and Methods: We analysed 393 consecutively hospitalized cirrhotic patients none of whom had active bacterial infection, glomerular filtration rate (GFR)
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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