studies

418A AASLD ABSTRACTS HEPATOLOGY, October, 2015
Univariate analysis compared baseline factors.Baseline factors
independently associated with HD after TACE were identified
with Cox regression. Results:51 patients(28%)experienced an
HD event within 90 days of TACE.Median time to decompensation
event after first TACE was 52 days.On univariate analysis,
alkaline phosphatase(ALP), total bilirubin(TB), albumin,
INR, MELD, being within Milan or UCSF criteria, history of
HD event within 1 year of TACE significantly differed between
decompensated and compensated groups(TABLE).Cox regression
model identified a decompensation event within 1 year
prior to TACE(HR 2.19,p=0.02), ALP(HR 1.003,p=0.007)and
being outside UCSF criteria(HR 0.49,p=0.02)as independently
associated with an HD event after TACE.TB, albumin, INR and
MELD were not. Conclusion:For patients with cirrhosis being
considered for TACE, absence of decompensating event within
1 year of TACE, HCC within UCSF criteria and low ALP are
associated with low risk of TACE-related HD.
Univariate Analysis
Disclosures:
The following authors have nothing to disclose: Dempsey Hughes, Fredric D.
Gordon, Keith E. Stuart, FW Nugent, Sebastian Flake, Mary Ann Simpson, Amir
A. Qamar
between pathological and radiological findings regarding
the number of nodules was found in 103/184(56%): 78
were underestimated and 25 overestimated by radiology.
10/40(25%) patients who were within Milan criteria, resulted
outside according to histology due to discrepancy in number
of nodules. Considering the diameter of the biggest nodule on
explant, discordance was observed in 158/181(87%): 93
were underestimated and 65 overestimated. 20 of 40(50%)
within Milan criteria on imaging, exceeded these due to
discrepancy in biggest nodule diameter. HCC recurrence
occurred in 29/184(16%) patients in a median of 37m (4-157)
post-LT. In Cox regression, pre-LT factors associated with HCC
recurrence were aFP>100 IU/ml (p3cm
(p3cm but different
aFP levels (22% in aFP100, p=0.003).
The same pre-LT factors were also significantly associated with
HCC-related mortality post-LT. Conclusion: In HCC transplanted
patients there was a marked discrepancy between radiological
findings and pathological description of the explant. The best
predictors of HCC recurrence were pre-LT aFP and diameter
of the biggest nodule. Combined together could allow us to
include in the current transplant criteria patients with biggest
nodule diameter>3cm if aFP