studies

296A AASLD ABSTRACTS HEPATOLOGY, October, 2015
95%CI: 1.14-1.48), also among hepatitis-free participants
(OR multivariable
=1.19; 95%CI: 1.05-1.34). Adding liver function
tests to OPN improved the discrimination of those subjects who
developed HCC (AUC=0.86) while AFP didn’t improve the
model. In contrast, within two years of HCC diagnosis, the
combination of OPN and AFP was best able to predict HCC
risk (AUC=0.88) while further adjustment for liver function tests
or chronic hepatitis B/C infection did not improve the model.
Conclusions: In this study, pre-diagnostic serum OPN concentration
was associated with higher risk of first incident HCC
and the association was stronger among cases diagnosed
during the first two years of follow-up. OPN in combination
with liver function tests improved the detection of HCC in this
low-risk population. However, OPN in combination with AFP
was the best predictive model for detection of HCC within
two years of follow-up and did not change substantially after
excluding hepatitis positive participants, or after adjustment for
biomarkers of liver function.
Disclosures:
The following authors have nothing to disclose: Talita Duarte-Salles, Sandeep
Misra, Magdalena Stepien, Mazda Jenab, Pierre Hainaut, Laura Beretta
171
Risk factors of complications in liver adenomatosis.
Barbara Willandt 1 , Ragna Vanslembrouck 2 , Raymond Aerts 3 ,
Baki Topal 3 , Wim Laleman 1 , David Cassiman 1 , Schalk Van Der
Merwe 1 , Werner Van Steenbergen 1 , Chris Verslype 1 , Frederik
Nevens 1 ; 1 Hepatology, UZ Leuven, Leuven, Belgium; 2 Radiology,
UZ Leuven, Leuven, Belgium; 3 Adominal Surgery, UZ Leuven, Leuven,
Belgium
Introduction & aims: Hepatic adenomatosis is a disorder characterized
by multiple adenomas in an otherwise normal liver,
originally defined as a distinct entity from a solitary hepatocellular
adenoma. Due to the rarity of the disorder there is
lack of consensus about treatment strategies. We explored the
risk factors of complications and whether the genotype-phenotype
classification used for solitary hepatic adenomas has the
same prognostic significance in this disorder. Methods: We
re-analyzed 35 patients with liver adenomatosis : > 10-20
nodules (n=23pts) and > 20 (n=12pts); 6 patients with 5-10
nodules were evaluated separately; 2 pts excluded because
of glycogen storage disease. Biopsies, taken in the largest
nodules, were available in 30 patients. Results: The median
follow-up period was 6 years (range 1-24 years). All patients
(median age 38 year, range 18-54) were female except one
and 91% of them had a history of long term use of oral contraceptives
(median 17 years, range 5-34). BMI was > 25 kg/m 2
in 61% of patients and steatosis of the surrounding liver tissue
was present in 60%. Histological subtype analysis showed: 17
patients (63%) with inflammatory adenomas - in one patient
associated with β-catenin activated lesions, 9 patients (33%)
with HNF1-α mutation positive lesions of which 2 patients also
had a β-catenin activated lesion and in 1 patient only β-catenin
activated adenomata were identified. Inflammatory adenomas
were clearly associated with high BMI (> 25 kg/m 2 ) and steatosis
(13/16 (p