studies

272A AASLD ABSTRACTS HEPATOLOGY, October, 2015
123
Serum Alanine Aminotransferase (ALT) and Hepatitis
B Virus (HBV) DNA Flares In Pregnant and Postpartum
Women With Chronic Hepatitis B (CHB)
Christine Y. Chang 1 , Natali Aziz 2 , Huy N. Trinh 3 , Mindie H.
Nguyen 1 ; 1 Division of Gastroenterology and Hepatology, Stanford
University Medical Center, Palo Alto, CA; 2 Obsterics and Gynecology,
Stanford University School of Medicine, Stanford, CA; 3 San
Jose Gastroenterology, San Jose, CA
Background: During pregnancy, alterations in the immune system
allow the mother to tolerate the semiallogenic fetus, but
their effects on CHB activity are poorly understood. Methods:
To examine flares in HBV DNA (≥1 log increase from baseline)
and/or ALT (≥2xULN or baseline) during pregnancy and 6
months postpartum, we performed a retrospective study of 88
pregnancies in 74 CHB expectant mothers who were not on
anti-HBV therapy for ≥1 year prior to pregnancy at 2 U.S.
centers. Results: Most were Asian (93%), with a mean age
of 32±4, median gravida of 2 (IQR: 1-3), and median parity
of 0 (IQR: 0-1). Mean log HBV DNA was 2.0±0.8 IU/mL at
baseline in low HBV DNA mothers (≤2000 IU/mL, n=33), and
6.1±2.0 in high HBV DNA mothers (>2000 IU/mL, n=55). At
baseline, low HBV DNA mothers had lower ALT (≤x2ULN: 82%
vs. 47%, p=0.001) and were more likely to be HBeAg- (90%
vs. 44%, p