studies

1000A AASLD ABSTRACTS HEPATOLOGY, October, 2015
.Only results obtained with at least ten successful acquisitions,
success rate of at least 60% and IQR/LSM ratio less than 30%
were considered reliable. Metavir liver fibrosis stages were
assessed by the same pathologist experienced blinded to the
results of LSM. Statistical analysis was made according to SAS.
RESULTS: Statistical analysis was conducted in 109 patients,
26 patients were excluded for unreliable LB or LSM. Sex ratio
M/F was 1.65, mean age was 38.6 years. The mean biopsy
length was 26.4mm. The distribution of liver fibrosis according
to the METAVIR score were: F0 (n = 17) (15.5%),F1: n = 51
(46.7% ) F2: n = 20 (18.3%), F3: n = 15 (13.7%) and F4: n
= 6 (5.5%). The mean delay between LSM and LB was 6 days,
the mean acquisition success rate was 95% and the median
IQR / LSM ratio was 14.6%. The area under receiver –operating
characteristic curves were 0.87 (95%confidence intervals
0.80-0.94) for F≥2, 0.90 (0.82-0.98) for F≥ 3 and 0.93
(0.83-1)for F4.Optimal LSM cut-off values were 7.1 for ≥F2,8.6
for≥F3 and 12 for F4 by maximizing of sensitivity and specificity.In
univariate analysis, LSM was significantly correlated with
Metavir fibrosis stage,activity grade,gender, and biopsy length
.In multivariate analysis, LSM was significantly correlated only
with Metavir fibrosis stage,activity grade, and biopsy length.
CONCLUSION: LSM is an accurate method for assessment liver
fibrosis in patients with chronic hepatitis B e negative with high
performance diagnostic for cirrhosis.
Disclosures:
Salah Sahraoui - Employment: bms, roche
Nabil Debzi - Speaking and Teaching: roche, msd, bms, Janssen, Abbvie
The following authors have nothing to disclose: Nawal Guessab, Nawel Afredj,
Rafik Kerbouche, Ibtissem Ouled Cheikh, Sonia Ait Younes, Samir Gourari,
Yazid Chikhi, Salima Cheraitia, Mohamed Merniz, François Montestruc, Saadi
Berkane
1622
Evaluation of HBV infection status in spouses of
HBsAg-positive individuals
Ebru Dik, Selma Tosun, Seher A. Coskuner, Alpay Ari, Meltem
Avci; Infectious Diseases, Bozyaka Education and Research Hospital,
Izmir, Turkey
Objective: The transmission of infection through sexual intercourse
is one of the most common routes of transmission for
hepatitis B virus. Therefore the spouses of HBsAg-positive
individuals must be screened for HBsAg positivity. The aim
of the present study was to evaluate HBV infection status in
spouses of HBsAg-positive individuals. Method: Using face-toface
interview technique, a questionnaire was administered to
HBsAg-positive cases who were followed in Viral Hepatitis Outpatient
Clinics at zmir Bozyaka Education and Research Hospital
in order to evaluate HBV infection status in their spouses,
and the results were recorded if tests were available. Results:
The study included a total of 949 HBsAg-positive cases who
were aged 17 to 76 years. The spouses of 409 (43%) cases
were never tested for HBV infection. When the results of the
tested individuals were evaluated, the rate of HBsAg positivity
was 6% (n=32), rate of antiHBcIgG+AntiHBs positivity was
18%(n:96), rate of antiHBs positivity was 12%, rate of antiHBcIgG
positivity alone was 1%, and rate of negative results in all
HBV parameters was 62%. Conclusion: The data suggest that
not all spouses of the individuals were tested for HBV infection.
It is a striking finding that HBV infection status was unknown
in 43% of the spouses. The rate of HBsAg positivity was 6%
and the rate of immunization was very low (12%). AntiHBcIg-
G+AntiHBs positivity was 18%. These results suggest that HBV
transmission to the spouses from HBsAg-positive individuals is
common, but the awareness of the individuals was very low.
Low rate of testing and high rate of HBsAg positivity among
the spouses suggest that screening of spouses for HBV infection
must not be neglected.
Disclosures:
The following authors have nothing to disclose: Ebru Dik, Selma Tosun, Seher A.
Coskuner, Alpay Ari, Meltem Avci
1623
Is booster beneficial after universal HBV vaccination?
Selma Tosun 1 , Erhun Kasirga 2 ; 1 Infectious Diseases, Bozyaka Education
and Research Hospital, Izmir, Turkey; 2 Pediatric Gastroenterology,
Celal Bayar University The Faculty of Medicine, Manisa,
Turkey
Objective: The infants are administered hepatitis B vaccination
after birth at 0, 1, and 6 months. HBV vaccine-induced
antibody titers are maintained in the blood for a long time
(possibly lifelong) in immunocompetent individuals. However,
there are some studies suggesting a considerable decrease
in antiHBs titers below protective level 7 to 8 years after HBV
vaccine administered immediately after birth. The studies also
indicate an excellent antiHBs response with a booster dose
of HBV vaccine. The aim of the present study was to evaluate
antiHBs response in children with or without a booster vaccine
dose after universal HBV vaccination. Method: The study
included primary school children who received HBV vaccine
after birth. The study subjects were divided into 2 groups and
of the students in Group 1, 157 received three booster doses of
HBV vaccine 7 to 9 years after national vaccination program.
Totally 142 students in Group 2 did not receive any vaccine
after the initial HBV vaccines administered after birth. AntiHBs
titers were studied in blood samples, and the students with a
antiHBs titer below 10 IU/mL were also tested for HBsAg and
antiHBcIgG . Results: The study included a total of 299 student
aged 7 to 12 years. The rate of positive antiHBs titers in students
that received three booster doses of vaccine in Group 1
was statistically significantly higher compared to the students
in the second group (p