studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 1301A
2245
Non-alcoholic fatty liver is not associated with incident
chronic kidney disease: a large histology based case
controlled study
Neeraj Saraf, Narendra S. Choudhary, Sanjiv Saigal, Naveen
Kumar, Rahul Rai, Dheeraj Gautam, Arvinder Soin; Hepatology,
Medanta Medicity, Gurgaon, India
Background: Non-alcoholic steatohepatitis or fibrosis is associated
with the increased prevalence of impaired kidney function.
It is not known whether non alcoholic fatty liver (NAFL)
which is steatosis without inflammation or fibrosis is associated
with renal impairment as these subjects are not candidates for
liver biopsy. Materials and methods: The study group included
all liver donors who underwent donor hepatectomy at our centre
and had a preoperative liver biopsy for various reasons
like, high body mass index, dyslipidemia, presence of metabolic
syndrome or evidence of liver steatosis on imaging. All
the subjects had negative viral markers. Non-alcoholic fatty
liver (NAFL) was defined as >5% hepatocytes having steatosis
and no changes of steatohepatitis and/or fibrosis. Subjects
with NAFL were compared with subjects with normal liver histology.
Estimated glomerular filtration rate was calculated with
Modification of Diet in Renal Disease (MDRD) and CKD-EPI
method. All subjects had assessment for proteinuria and serum
creatinine. Results: The study group aged 35±10.3 years and
mean BMI was 26±3.2 kg/m 2 . One hundred and eighty seven
adults having NAFL (80 males) were compared to 186 (88
males) subjects with normal liver histology (controls). Subjects
with steatosis had significantly higher body mass index
(26.8±3.5 versus 25.5±3.8 kg/m 2 , P