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940A AASLD ABSTRACTS HEPATOLOGY, October, 2015 this cohort, with 64% of the cohort having at least one highrisk parameter. Table 1 shows prevalence of high risk HRV parameters. SDNN and SDANN correlated with Child scores (p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 941A and dry BMI, mid-arm muscle circumference, SMI and VMI. Logistic regression analysis revealed that INR [O.R. 6.581 (95% C.I. 1.330 – 32.569), p = 0.021] and log-transformed leptin [O.R. 0.425 (0.221 – 0.816), p < 0.010] were independently associated with malnutrition. Conclusions: Low serum leptin and elevated INR are associated with malnutrition in hospitalized patients with cirrhosis and may represent biomarkers for early identification of malnutrition in this population. Disclosures: The following authors have nothing to disclose: Vikrant Rachakonda, Jaideep Behari Disclosures: Lewis R. Roberts - Grant/Research Support: Bristol Myers Squibb, ARIAD Pharmaceuticals, BTG, Wako Diagnostics, Inova Diagnostics, Gilead Sciences, Five Prime Therapeutics The following authors have nothing to disclose: Thoetchai Peeraphatdit, Niyada Naksuk, Roongruedee Chaiteerakij 1497 The World Congress of Gastroenterology Guidelines for the Diagnosis of Left Ventricular Diastolic Dysfunction Differ from the American Society of Echocardiography Standard Recommendation Thoetchai Peeraphatdit 1,2 , Niyada Naksuk 3 , Lewis R. Roberts 2 , Roongruedee Chaiteerakij 2,4 ; 1 Internal Medicine, University of Minnesota, Minneapolis, MN; 2 Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN; 3 Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN; 4 Medicine, Chulalongkorn University, Bangkok, Thailand Purpose: Diagnostic criteria for left ventricular diastolic dysfunction (LVDD) proposed by the World Congress of Gastroenterology (WCG) has never been tested and are different from the American Society of Echocardiography (ASE) criteria. This study determined the agreement of LVDD diagnosed by these two guidelines, the performance of the WCG criteria, and their prognostic values. Methods: We retrospectively enrolled 914 consecutive patients with normal left ventricular ejection fraction (LVEF) and available data on diastolic function undergoing liver transplant (LT) at a tertiary medical center between 1994 and 2014. According to the ASE, LVDD was diagnosed based on a stepwise approach using multiple parameters. However, by the WCG, LVDD was defined as an early to late ventricular filling velocities ratio (E/A) 200 ms. The agreement of LVDD diagnosed by the two guidelines was analyzed using the Kappa statistic. The performance of the WCG criteria was determined using the ASE criteria as a gold standard. Results: Mean age was 53.7±10.6 years; 65.2% were male. During 5.6±4.2 years follow up after LT, 21.6% patients had died. Overall LVEF was 65.8±5.1%. By the ASE criteria, 47.2% of patients had LVDD; whereas the prevalence of LVDD was 19.6%, 61.0%, 64.5% and 13.9% by the WCG criteria of E/A 200 ms, either one of the criteria, or both criteria, respectively. There was minimal agreement between LVDD diagnosed by the 2 WCG criteria (Kappa=0.10). Moreover, there was generally poor or slight agreement between the ASE and the WCG criteria (Kappa=0.08-0.18, Table). The WCG criteria had sensitivities of 50-70% and specificities of 58-62% (Table). However, in the multivariate Cox regression, only LVDD diagnosed by the WCG criterion of E/A
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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