studies

604A AASLD ABSTRACTS HEPATOLOGY, October, 2015
Disclosures:
The following authors have nothing to disclose: David I. Sherman, Waleed
Fateen, Minal J Sangwaiya, Paul Tadrous, Philip J. Shorvon
792
2D Shear Wave Elastography is not Superior to Transient
Elastography in Difficult-to-Scan Patients: A Comparative
Feasibility Study
Benjamin Staugaard 3 , Janne F. Hansen 3 , Belinda Mössner 3 ,
Bjørn S. Madsen 1 , Aleksander Krag 1 , Peer B. Christensen 3 ,
Maja Thiele 1,2 ; 1 Department of Gastroenterology and Hepatology,
Odense University Hospital, Odense C, Denmark; 2 OPEN,
Odense Patient data Exploratory Network, Odense University
Hospital, Odense, Denmark; 3 Department of Infectious Diseases,
Odense University Hospital, Odense, Denmark
Introduction: 2D shear wave elastography (2D-SWE) is a promising
new elastography technique. Some studies suggest that
2D-SWE reduce the number of invalid measurements otherwise
seen with transient elastography (TE), but a direct comparison
between the two techniques in difficult-to-scan patients
has not been performed. Methods: Single-center comparative
study to evaluate the feasibility of TE (Echosens FibroScan) and
2D-SWE (Supersonic Aixplorer). We included patients with
hepatitic C and alcoholic liver disease with a invalid TE at
their latest appointment. At inclusion, an experienced operator
re-examined patients with same-day TE and 2D-SWE. TE was
evaluated using standard quality criteria, while 2D-SWE quality
criteria mimicked TE criteria: SD/mean should be ≥ 30%.
Additionally, we judged 2D-SWE image quality subjectively:
A uniform colour-coded region of interest should remain stable
for 3 seconds and be at least 15 mm in diameter. Results:
From 10,247 TE examinations performed between 2007-14,
we identified 119 eligible patients and included 52 in the
study. The median age was 57 years and 60% were male.
The majority of patients were overweight (median BMI 31 kg/
cm 2 ; range 19-55; BMI ≥ 30 in 54% of patients). None of the
patients had ascites. The initial screening examination was a
failure in 13 of patients, while 39 patients had a unreliable
TE. At re-examination, TE and 2D-SWE were both feasible in
33 patients (63%). Seventeen patients had a valid TE, but an
invalid 2D-SWE (33%). In two patients, both TE and 2D-SWE
failed (4%). Both these patients were investigated with the XL
probe. The XL probe was used in a total of 31 patients. The
applicability of TE was superior to 2D-SWE, as TE was valid
in 96% of re-examined patients while 2D-SWE was valid in
63% (P