studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 999A
ing, others have challenged it. Limited data is available from
United States. Study Aim: Effect of C-section and formula feeding
on vertical transmission in a cohort of CHB pregnant mothers
from United States. Methods: Retrospective study (January
2005- June 2010) at a large integrated health care system in
Southern California. CHB pregnant mothers identified using
regional perinatal database. Inclusion criteria: age > 18 years,
positive serum HBsAg (hepatitis B surface antigen). Exclusion
criteria: negative/ false positive HBsAg; termination of pregnancy
or lost to follow up. Data Collection; demographics,
first live-birth pregnancy reviewed, mode of delivery, breast
feeding (defined as breastfeeding for ≥2 weeks after birth),
maternal hepatitis B e antigen (HBeAg), and HBsAg testing of
infants at 9-18 months of age. Lost to follow up if child not seen
at 9-18 months of age. Fisher’s exact test used to determine
statistical significance. Results: A total of 472 infants were born
to 462 CHB mothers (mean maternal age 32.5 years, range
18-45; 78.8% Asian-Pacific Islanders). 308 (66.7%) delivered
vaginally and 154 (33.3%) through C-section. All C-sections
were performed for obstetrical indications, with labor arrest
being most common. 384 (83.1%) mothers breast-fed after
delivery. Mode of feeding could not be established for 13
(2.8%) mothers. Hepatitis Be antigen (HBeAg) status of mothers
outlined in table 1. Only 1 infant (delivered vaginally and
breast-fed) born to HBeAg positive mother (unknown antenatal
HBV viral load) had reactive HBsAg. No statistically significant
difference found for risk of vertical transmission between
mothers who breastfed vs. formula feeding (1/230 vs. 0/35;
p>.05); normal vaginal vs. cesarean-section delivery (1/185
vs. 0/85; p>.05). Limitation of data: 104 (26.2%) infants did
not have HBsAg tested at 9-18 months follow up. Missing antenatal
HBeAg and HBV viral load data for mothers. Conclusion:
C-section and formula feeding did not reduce vertical transmission
risk in cohort of CHB pregnant mothers from United States.
Table 1 Maternal practices: Infant feeding, delivery mode
HBV-related chronic liver diseases needs to be further studied,
especially regarding the role of hepcidin. Methods: In the
present study, we investigated the association between serum
hepcidin, iron metabolism and the clinical indictors in the
patients with HBV-related chronic liver diseases in a case-control
study(2013-2015). A total of 318 subjects were included
in the study, including 78 cases with HBV-related chronic hepatitis,
85 cases with HBV-related liver cirrhosis, 77 cases with
HBV-related hepatocellular carcinomar(HCC), and 78 healthy
individuals as controls. Results: Compared with the healthy controls,
all groups of cases had significantly higher levels of serum
ferritin, and much lower levels of serum hepcidin. Compared
with HBV-related chronic hepatitis, the levels of HBV-DNA loading,
serum iron, total iron binding force(TIBC) and serum transferrin
were more lower in the patients with cirrhosis and HCC,
and the serum hepcidin levels were obviously higher. The level
of serum ferritin was increased with the severity of liver fibrosis
and inflammation activity. The multiple linear regression analysis
showed that serum hepcidin levels had obvious correlation
with HBV-DNA loading levels (β=-0.277, t=-4.438, P