studies

HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 1137A
cirrhosis etiology in cirrhotic patients undergoing screening
for HCC. Methods: This was a case-control study conducted
on patients with cirrhosis with and without HCC identified via
ICD-9 diagnosis codes retrospectively from 1990-2014 in a
large state-wide database who underwent surveillance imaging.
HCC was diagnosed by imaging and/or biopsy. The cirrhosis
cohort without HCC was determined by absence of HCC
on last imaging study. AFP levels within 90 days of imaging
were abstracted. The sensitivity and specificity of AFP levels
was determined for HCC diagnosis in HCV cirrhosis, non-viral
cirrhosis and the entire cohort. AFP thresholds were explored
based on previous literature by ROC analysis and group comparisons
were performed by Chi-square tests. Results: 10,481
patients with cirrhosis were identified, 6166 patients excluded
(no AFP levels, no AFP levels within 90 days, or AFP >500).
1641 patients with HCC were identified, 402 excluded as
HCC diagnosed before first imaging study. 3371 patients with
cirrhosis and 551 HCC patients were analyzed. Patients were
predominantly white (87 % without HCC, 86 % with HCC),
and male (59% cirrhotic cohort, 72% HCC cohort). Patients
with cirrhosis were younger (54 vs 57 years p