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398A AASLD ABSTRACTS HEPATOLOGY, October, 2015 needle-aspiration biopsy specimens of 44 HCC patients (20 in the HBV group, 19 in the HCV group and 5 in the NASH group) were subjected to real-time PCR to measure expression levels of TAA mRNAs in tumor tissues. Results IFN-g ELISpot assay revealed that immune responses to the p53-derived epitope (positive rates: 20.7% in the HBV group, 5.0% in the HCV group and 0% in the NASH group), and to the MRP3-derived epitope (positive rates: 20.7% in the HBV group, 2.5% in the HCV group and 5.6% in the NASH group) were significantly induced in the HBV group than in other groups (p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 399A median survival (MS) significantly improved from 1990-2011 in localized, regional and distant metastases with CDS. In the 65-75 age population MS improved only in CDS localized disease; 7 months (1990-2000) to 9.8 months (2001-2011). In the 75+ age population, the MS from 1990-2000 and 2001- 2011 did not show significant change regardless of extent of disease; localized CDS patients was 6.6 months (1990-2000) compared to 6 months (2001-2011). Conclusion: Over the last two decades, there has been an increased incidence in patients receiving CDS likely due to advancements in hepatic resection. The overall survival in the elderly population with CDS (75+) though remains poor throughout the last two decades regardless of the extent of the disease. Advanced age seems to be a poor prognostic factor even with CDS, suggesting future study in this age population. Disclosures: The following authors have nothing to disclose: George Cholankeril, Ponnandai Somasundar 373 Patients with alcohol compared to HCV-related hepatocellular carcinoma (HCC) have a reduced survival. Results of a Nationwide study. Charlotte E. Costentin 1 , Nathalie GOUTTE 2 , Philippe Sogni 3 , Bruno Falissard 4 , Noelle Bendersky 5 , Olivier Farges 2 ; 1 Hepatology, Hôpital Henri Mondor, Creteil, France; 2 Hepatology – Hepato-biliary surgery, Beaujon Hospital, Clichy, France; 3 Hepatology, Cochin Hospital, Paris, France; 4 biostatistique, Paris-Sud University, INSERM, Paris, France; 5 Medical Informatics, Beaujon Hospital, Clichy, France Introduction: Data on alcohol-related HCC are scarce. The aim of this study was to describe the incidence, management and prognosis of alcohol compared to HCV-related HCC, at a national level. Patients and Methods: French healthcare databases were screened to identify all adult patients who were hospitalized between 2007 and 2012 with a diagnosis of HCC. Incident cases of HCC were selected by defining the entry point as a first admission in 2009. Demographic data, associated conditions, underlying liver disease and etiology, as well as the type (teaching, general, private, charitable), location, and annual HCC-caseload of the hospitals where patients were first managed (1st tertile 45), were retrieved. Treatments were divided into curative (liver transplantation, resection, radiofrequency) or not. Survival of incident-cases was computed from the time of diagnosis and adjusted for potential confounding variables. In order to compare two homogeneous populations of alcohol and HCV-related HCC, patients with unknown etiology of liver disease, mixed etiologies or HBV were excluded, Results: Between 2009 and 2012, the study population included 13,942 (83.4%) incident-cases of alcohol and 2,774 (16.6%) HCV-related HCC. The incidence of alcohol- and HCV-related HCC varied up to 2 fold from one mainland region to another, and in some regions, alcohol accounted for up to 96% of HCC. Alcohol- compared to HCV-related HCC occurred more often in men (89.2% vs 63.7% p
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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