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402A AASLD ABSTRACTS HEPATOLOGY, October, 2015 were not adherent to surveillance; and 21 (6%) had chronic liver disease without a clear cirrhosis. Patients diagnosed out of surveillance had more advanced BCLC (p
HEPATOLOGY, VOLUME 62, NUMBER 1 (SUPPL) AASLD ABSTRACTS 403A 381 Prediction of Hepatocellular Carcinoma Risk in Patients with Cirrhosis: Validation of ADRESS–HCC Model Ju Dong Yang, Hager Ahmed Mohammed, Jonggi Choi, Gregory J. Gores, Lewis R. Roberts, W. Ray Kim; Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN Background/Aims: ADRESS-HCC is a model to predict the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis [Cancer 2014;3485]. It incorporates age, diabetes, race, etiology and severity of cirrhosis, and sex. In this study, we validate the model in an independent cohort of patients. Methods: Of all cirrhotic patients seen at Mayo Clinic Rochester between January 2006 and December 2011, those who had liver images (US, CT, or MRI) at baseline and at follow up more than 6 months from baseline were included. The ADRESS risk score was calculated by the following: score= [age]*0.0532+ [1 for diabetes]*0.2135 + [1 for nonwhite/Hispanic]*0.2058 + [1 for metabolic/alcohol etiology]*0.3509 + [1 for viral etiology]*1.246 + [1 for male]*0.5114 + [Child-Turcotte-Pugh (CTP) score]*0.1170. Observed incidence of HCC was compared to the model’s prediction. Results: A total of 739 cirrhotic patients met the eligibility criteria. The mean age was 57.4 years, with 59% men, 90% non-Hispanic White and 34% diabetic. The etiology of liver disease was alcoholic in 32%, viral in 23% and metabolic in 23%. The mean CTP score was 8. After a median follow up of 38 months, 69 (9%) patients developed HCC. The median ADRESS score was 5.01 (interquartile range: 4.44-5.46). Figure divides patients into 3 groups by the ADRESS score quartiles: the top (high risk) quartile (hazard ratio [HR]=6.8; 95%CI=2.9-20.2) and the middle two quartiles (HR=3.2; 95%CI=1.4-9.4) had a significantly higher incidence of HCC compare to the lowest risk quartile. When the surveillance threshold (ADRESS=4.67 with predicted annual incidence=1.5%) was applied, 0.97% of patients developed HCC in the first 18 months. Conclusions: Based on an independent cohort of cirrhotic patients, we validate ADRESS-HCC model as a useful tool for predicting the risk of HCC among patients with cirrhosis and identifying candidates for surveillance. Disclosures: Douglas Dieterich - Advisory Committees or Review Panels: Gilead, BMS, Abbvie, Janssen, Merck, Achillion The following authors have nothing to disclose: Beatriz Minguez, Ayse Aytaman, Meritxell Ventura-Cots, Maaz B. Badshah, Caitlin C. Citti, Heather L. Platt, Ting-Yi Chen, Luciana Kikuchi, Sonja Marcus, Michael Yin, Judith Aberg, Myron E. Schwartz, Norbert Bräu Disclosures: Gregory J. Gores - Advisory Committees or Review Panels: Conatus Lewis R. Roberts - Grant/Research Support: Bristol Myers Squibb, ARIAD Pharmaceuticals, BTG, Wako Diagnostics, Inova Diagnostics, Gilead Sciences, Five Prime Therapeutics W. Ray Kim - Advisory Committees or Review Panels: Bristol Myers Squibb, Gilead Sciences, Abbvie, Merck The following authors have nothing to disclose: Ju Dong Yang, Hager Ahmed Mohammed, Jonggi Choi 382 The life time frequency and interval of treatments define the prognosis of hepatocellular carcinoma after radical radiofrequency ablation therapy Takamasa Ohki, Yuki Hayata, Satoshi Kawamura, Daisaku Ito, Koki Kawanishi, Kentaro Kojima, Michiharu Seki, Nobuo Toda, Kazumi Tagawa; Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan Backgrounds and Aims: Hepatocellular carcinoma (HCC) frequently recurs even after curative radiofrequency ablation (RFA) therapy and the recurrence rate is approximately 50% within 3 years. Thus, the treatment strategy after HCC recurrence is very important to achieve a long term survival. We analyzed the life time frequency and interval of treatments to evaluate their impacts on overall survival (OS). Patients and methods: In this retrospective study, we enrolled 305 naïve HCC patients who were curatively treated with RFA between January 1 2000 and December 31 2010. The last follow-up date was December 31 2014. The rate of life time frequency of treatments per year (LFT rate) was calculated as total numbers of treatments divided by observational year. The total numbers of treatments were defined as sum of frequency of RFA and trans-catheter chemo-embolization or infusion (TACE or TAI) times. Patients were stratified into four groups to compare the OS according to LFT rate: group A; LFT rate < 0.5 N = 53, group B; 0.5 ≤ LFT rate < 1.0 N = 69, group C; 1.0 ≤ LFT rate < 2.0 N = 103, and group D; 2.0 ≤ LFT rate N = 80. Results: During the mean follow-up of 4.7 years, the life time frequency of treatments was 5.2 times on average. The frequency of each treatment modality was as follows: RFA 2.8 and TACE or TAI 2.3 times. One-hundred fifty-eight patients died during the follow-up period, showing cumulative survival rates at 3, 5 and
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1000A AASLD ABSTRACTS HEPATOLOGY, O
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1312A AUTHOR INDEX HEPATOLOGY, Octo
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1366A CATEGORY INDEX HEPATOLOGY, Oc
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